6 Result(s)
within
Robert M. Samstein
English
Biomedicine, general
Infectious Diseases
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Article
Open AccessAuthor Correction: Gemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial
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Article
Open AccessGemcitabine and cisplatin plus nivolumab as organ-sparing treatment for muscle-invasive bladder cancer: a phase 2 trial
Cystectomy is a standard treatment for muscle-invasive bladder cancer (MIBC), but it is life-altering. We initiated a phase 2 study in which patients with MIBC received four cycles of gemcitabine, cisplatin, p...
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Article
Immunogenic neoantigens derived from gene fusions stimulate T cell responses
Anti-tumor immunity is driven by self versus non-self discrimination. Many immunotherapeutic approaches to cancer have taken advantage of tumor neoantigens derived from somatic mutations. Here, we demonstrate ...
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Article
Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells
The transcription factor Foxp3 is essential for the function of regulatory T cells (Treg cells). Rudensky and colleagues show binding of Foxp3 poises target genes for repression and, after activation of Treg cell...
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Article
Transcription factor Foxp3 and its protein partners form a complex regulatory network
The transcription factor Foxp3 is essential for the function of regulatory T cells. Rudensky and colleagues show Foxp3 participates in large protein complexes that regulate gene expression of many of these com...
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Article
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells
Here we investigated the potential role of bone-resorbing osteoclasts in homeostasis and stress-induced mobilization of hematopoietic progenitors. Different stress situations induced activity of osteoclasts (O...
