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  1. Article

    The need for increased pragmatism in cardiovascular clinical trials

    The majority of cardiovascular randomized controlled trials (RCTs) test interventions in selected patient populations under explicitly protocol-defined settings. Although these ‘explanatory’ trial designs opti...

    Muhammad Shariq Usman, Harriette G. C. Van Spall… in Nature Reviews Cardiology (2022)

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  2. Article

    Open Access

    Glycemic status, non-traditional risk and left ventricular structure and function in the Jackson Heart Study

    Left ventricular structure and function abnormalities may be an early marker of cardiomyopathy among African Americans with diabetes (DM) even in the absence of coronary artery disease (CAD), arrhythmia, valvu...

    Chizobam Ani, David Shavlik, Synnove Knutsen… in BMC Cardiovascular Disorders (2022)

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    Article

    Update on the Impact of Comorbidities on the Efficacy and Safety of Heart Failure Medications

    Multiple newer medications benefit patients with heart failure with reduced ejection fraction (HFrEF). While these therapies benefit the broad population with HFrEF, the efficacy and safety of these therapies ...

    Christine Chow, Robert J. Mentz, Stephen J. Greene in Current Heart Failure Reports (2021)

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    Article

    Targeting Natriuretic Peptide Levels in Heart Failure with Therapy: Does “X” Really Mark the Spot?

    Explore controversial biomarker-guided management of patients with heart failure (HF) with reduced ejection fraction.

    Juliette K. Logan, Robert J. Mentz in Current Heart Failure Reports (2019)

  5. No Access

    Article

    Global Variations in Patient Populations and Outcomes in Heart Failure Clinical Trials

    Heart failure is a global pandemic and there has been a growing effort to enroll patients from different geographical regions in randomized controlled trials. In this review, we examined regional variation in ...

    Chidiebube Egwim, Brittany Dixon, Andrew P. Ambrosy… in Current Heart Failure Reports (2017)

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    Article

    Comorbidities in Heart Failure: Are There Gender Differences?

    Compared to men, women with heart failure (HF) are often older, smoke less, and have more preserved ejection fraction (EF) and hypertensive HF rather than HF of ischemic etiology. Gender-stratified outcomes on...

    Ingrid Hopper, Dipak Kotecha, Ken Lee Chin… in Current Heart Failure Reports (2016)

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    Article

    Pathophysiology and clinical evaluation of acute heart failure

  8. Acute heart failure (AHF) is a complex syndrome characterized by the worsening of signs and symptoms of heart failure

  9. ...

    10. Robert J. Mentz, Christopher M. O'Connor in Nature Reviews Cardiology (2016)

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    Article

    Global Perspectives in Hospitalized Heart Failure: Regional and Ethnic Variation in Patient Characteristics, Management, and Outcomes

    Heart failure (HF) is a public health problem of global proportions afflicting more than 25 million patients worldwide. Despite stable or declining per capita hospitalization rates in the USA and several Europ...

    Andrew P. Ambrosy, Mihai Gheorghiade, Ovidiu Chioncel… in Current Heart Failure Reports (2014)