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Article
Expression of a novel peptide derived from PCNA damages DNA and reverses cisplatin resistance
An 8 amino acid peptide sequence derived from proliferating cell nuclear antigen (PCNA) has been shown to effectively kill several breast cancer and neuroblastoma cell lines when added exogenously to cell cult...
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Article
Effects of gemcitabine and araC on in vitro DNA synthesis mediated by the human breast cell DNA synthesome
Purpose: Gemcitabine (dFdC) and cytarabine (araC) are both analogs of deoxycytidine. Gemcitabine is a relatively new drug that has been shown in both clinical trials and in vitro systems to have more potent anti...
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Article
Ara-C affects formation of cancer cell DNA synthesome replication intermediates
Purpose: An intact and fully functional multiprotein DNA replication complex (DNA synthesome) from human as well as from murine mammary carcinoma cells was first isolated and characterized in our laboratory. The...
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Article
The human cell multiprotein DNA replication complex (MRC): the effect of camptothecin on its ability to support in vitro DNA synthesis
Purpose : We have previously reported on the isolation and characterization of a multiprotein DNA replication complex (MRC) from HeLa cells that fully supports in vitro DNA replication. Based upon its ability to...