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  1. No Access

    Article

    Expression of a novel peptide derived from PCNA damages DNA and reverses cisplatin resistance

    An 8 amino acid peptide sequence derived from proliferating cell nuclear antigen (PCNA) has been shown to effectively kill several breast cancer and neuroblastoma cell lines when added exogenously to cell cult...

    Robert G. Lingeman, Robert J. Hickey… in Cancer Chemotherapy and Pharmacology (2014)

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    Article

    Effects of gemcitabine and araC on in vitro DNA synthesis mediated by the human breast cell DNA synthesome

    Purpose: Gemcitabine (dFdC) and cytarabine (araC) are both analogs of deoxycytidine. Gemcitabine is a relatively new drug that has been shown in both clinical trials and in vitro systems to have more potent anti...

    Hai Yan Jiang, Robert J. Hickey, Waleed Abdel-Aziz… in Cancer Chemotherapy and Pharmacology (2000)

  3. No Access

    Article

    Ara-C affects formation of cancer cell DNA synthesome replication intermediates

    Purpose: An intact and fully functional multiprotein DNA replication complex (DNA synthesome) from human as well as from murine mammary carcinoma cells was first isolated and characterized in our laboratory. The...

    Waleed Abdel-Aziz, Hai-Yan Jiang, Robert J. Hickey… in Cancer Chemotherapy and Pharmacology (2000)

  4. No Access

    Article

    The human cell multiprotein DNA replication complex (MRC): the effect of camptothecin on its ability to support in vitro DNA synthesis

     Purpose : We have previously reported on the isolation and characterization of a multiprotein DNA replication complex (MRC) from HeLa cells that fully supports in vitro DNA replication. Based upon its ability to...

    Jennifer M. Coll, Robert J. Hickey, Yuetong Wei… in Cancer Chemotherapy and Pharmacology (1996)