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    Article

    The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2

    The integral membrane, Kunitz-type, serine protease inhibitors, HAI-1 and HAI-2, closely resemble one another structurally and with regard to their specificity and potency against proteases. Structural complem...

    Nanxi Huang, Robert B. Barndt, Dajun D. Lu, Qiaochu Wang, Shih-Ming Huang in Human Cell (2022)

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    Article

    Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation

    The pathophysiological functions of matriptase, a type 2 transmembrane serine protease, rely primarily on its enzymatic activity, which is under tight control through multiple mechanisms. Among those regulator...

    Bailing Jia, Hamishi A. Thompson, Robert B. Barndt, Yi-Lin Chiu, Mon-Juan Lee in Human Cell (2020)