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Article
Open AccessNociceptor-immune interactomes reveal insult-specific immune signatures of pain
Inflammatory pain results from the heightened sensitivity and reduced threshold of nociceptor sensory neurons due to exposure to inflammatory mediators. However, the cellular and transcriptional diversity of i...
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Article
Open AccessDerivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice
Central nervous system (CNS) lesions become surrounded by neuroprotective borders of newly proliferated reactive astrocytes; however, fundamental features of these cells are poorly understood. Here we show tha...
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Article
Open AccessClinically relevant small-molecule promotes nerve repair and visual function recovery
Adult mammalian injured axons regenerate over short-distance in the peripheral nervous system (PNS) while the axons in the central nervous system (CNS) are unable to regrow after injury. Here, we demonstrated ...