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  1. No Access

    Article

    GDF10 is a signal for axonal sprouting and functional recovery after stroke

    Stroke is the leading cause of adult disability. This study shows that the secreted factor GDF10 is a signal for the formation of new brain connections that lead to recovery after stroke and can be manipulated...

    Songlin Li, Esther H Nie, Yuqin Yin, Larry I Benowitz, Spencer Tung… in Nature Neuroscience (2015)

  2. No Access

    Article

    Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

    Although the cerebral cortex is organized into six excitatory neuronal layers, it is unclear whether glial cells show distinct layering. In the present study, we developed a high-content pipeline, the large-ar...

    Omer Ali Bayraktar, Theresa Bartels, Staffan Holmqvist… in Nature Neuroscience (2020)

  3. Article

    Open Access

    Clinically relevant small-molecule promotes nerve repair and visual function recovery

    Adult mammalian injured axons regenerate over short-distance in the peripheral nervous system (PNS) while the axons in the central nervous system (CNS) are unable to regrow after injury. Here, we demonstrated ...

    Ngan Pan Bennett Au, Gajendra Kumar, Pallavi Asthana… in npj Regenerative Medicine (2022)

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  4. No Access

    Article

    Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice

    Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated from oligodendrocyte precursor cells (OPCs) that express neurotransmitter receptors. However, the mechanisms that affe...

    Tsai-Yi Lu, Priyanka Hanumaihgari, Eric T. Hsu, Amit Agarwal… in Nature Neuroscience (2023)

  5. Article

    Open Access

    Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice

    Central nervous system (CNS) lesions become surrounded by neuroprotective borders of newly proliferated reactive astrocytes; however, fundamental features of these cells are poorly understood. Here we show tha...

    Timothy M. O’Shea, Yan Ao, Shinong Wang, Yilong Ren, Amy L. Cheng… in Nature Neuroscience (2024)

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  6. Article

    Open Access

    Nociceptor-immune interactomes reveal insult-specific immune signatures of pain

    Inflammatory pain results from the heightened sensitivity and reduced threshold of nociceptor sensory neurons due to exposure to inflammatory mediators. However, the cellular and transcriptional diversity of i...

    Aakanksha Jain, Benjamin M. Gyori, Sara Hakim, Ashish Jain, Liang Sun… in Nature Immunology (2024)

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