26 Result(s)
within
Reynold A. Panettieri Jr
Pneumology/Respiratory System
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Article
Open AccessPrecision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery
Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and physiologically relevant ex vivo model for studying the intricacies of lung diseases, including fibrosis, injury, repair, and host defense m...
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Open AccessEditorial for special issue—human precision cut lung slices: an Ex vivo platform for therapeutic target discovery and drug testing in lung disease
Publications utilizing precision cut lung slices (PCLS) steadily increased from the 1970’s, with a significant increase in 2010, to tripling by 2023. PCLS have been used to study a vast array of pulmonary dise...
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Article
Open AccessRhinovirus induces airway remodeling: what are the physiological consequences?
Rhinovirus infections commonly evoke asthma exacerbations in children and adults. Recurrent asthma exacerbations are associated with injury-repair responses in the airways that collectively contribute to airwa...
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Open AccessThe effects of benralizumab on airway geometry and dynamics in severe eosinophilic asthma: a single-arm study design exploring a functional respiratory imaging approach
Severe eosinophilic asthma (SEA) is characterised by elevated blood/sputum eosinophil counts and airway inflammation, which can lead to mucus plug-mediated airway obstruction, increased exacerbation frequency,...
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Article
Open AccessChildhood asthma diagnoses declined during the COVID-19 pandemic in the United States
Prior studies have documented declines in pediatric asthma exacerbations and asthma-related health care utilization during the COVID-19 pandemic, but less is known about the incidence of asthma during the pand...
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Article
Open AccessCEBPD modulates the airway smooth muscle transcriptomic response to glucocorticoids
CCAAT/Enhancer Binding Protein D (CEBPD), a pleiotropic glucocorticoid-responsive transcription factor, modulates inflammatory responses. Of relevance to asthma, expression of CEBPD in airway smooth muscle (ASM) ...
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Article
Open AccessFFAR1 activation attenuates histamine-induced myosin light chain phosphorylation and cortical tension development in human airway smooth muscle cells
Activation of free fatty acid receptors (FFAR1 and FFAR4) which are G protein-coupled receptors (GPCRs) with established (patho)physiological roles in a variety of obesity-related disorders, induce human airwa...
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Article
Open AccessDexamethasone rescues TGF-β1-mediated β2-adrenergic receptor dysfunction and attenuates phosphodiesterase 4D expression in human airway smooth muscle cells
Glucocorticoids (GCs) and β2-adrenergic receptor (β2AR) agonists improve asthma outcomes in most patients. GCs also modulate gene expression in human airway smooth muscle (HASM), thereby attenuating airway inflam...
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Article
Open AccessSalicylic acid amplifies Carbachol-induced bronchoconstriction in human precision-cut lung slices
Asthma exacerbations evoke emergency room visits, progressive loss of lung function and increased mortality. Environmental and industrial toxicants exacerbate asthma, although the underlying mechanisms are unk...
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Article
Open AccessThank you and farewell after 15 years editing Respiratory Research
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Article
Open AccessModulation of airway hyperresponsiveness by rhinovirus exposure
Rhinovirus (RV) exposure has been implicated in childhood development of wheeze evoking asthma and exacerbations of underlying airways disease. Studies such as the Copenhagen Prospective Studies on Asthma in C...
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Article
Open AccessSevere Asthma: Challenges and Precision Approaches to Therapy
Current therapies are inadequate for patients with severe asthma. The development of biomarkers and novel targeted therapies should allow for the introduction of precision medicine for patients with severe ast...
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Article
Open AccessUpregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis
Pirfenidone was recently approved for treatment of idiopathic pulmonary fibrosis. However, the therapeutic dose of pirfenidone is very high, causing side effects that limit its doses and therapeutic effectiven...
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Article
Open AccessAsthma in the elderly: a study of the role of vitamin D
Asthma in the elderly is poorly understood and vitamin D deficiency and insufficiency are very common in older individuals. We studied the role of vitamin D in elderly asthmatics.
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Article
Open AccessReviewer acknowledgement 2013
The editors of Respiratory Research would like to thank all of our reviewers who have contributed to the journal in Volume 14 (2013).
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Article
Open AccessThe effect of multiple allergen immunotherapy on exhaled nitric oxide in adults with allergic rhinitis
There is a lack of objective measures of the clinical efficacy of allergen immunotherapy which relies on patients’ perception about the effect of this treatment. We studied whether the fraction of exhaled nitr...
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Open AccessReviewer acknowledgement 2012
The editors of Respiratory Research would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2012).
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Vitamin D Modulates Airway Smooth Muscle Function
Asthma is a disease that manifests as variable airflow obstruction, bronchial hyperresponsiveness, and airway inflammation, and that evokes symptoms of wheezing, dyspnea on exertion, cough, and mucus productio...
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Article
Open AccessExpression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFα and IL-13
During pregnancy asthma may remain stable, improve or worsen. The factors underlying the deleterious effect of pregnancy on asthma remain unknown. Oxytocin is a neurohypophyseal protein that regulates a number...
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Article
Open AccessAnaphylatoxin C3a receptors in asthma
The complement system forms the central core of innate immunity but also mediates a variety of inflammatory responses. Anaphylatoxin C3a, which is generated as a byproduct of complement activation, has long be...
