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  1. No Access

    Article

    Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome

    Cancer immunotherapy with chimeric antigen receptor (CAR) T cells can cause immune effector cell-associated neurotoxicity syndrome (ICANS). However, the molecular mechanisms leading to ICANS are not well under...

    Janaki Manoja Vinnakota, Francesca Biavasco, Marius Schwabenland… in Nature Cancer (2024)

  2. Article

    Open Access

    Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells

    Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied b...

    Yu Wei Zhang, Julian Mess, Nadim Aizarani, Pankaj Mishra… in Nature Cell Biology (2022)

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    Article

    APC/CCdh1 regulates the balance between maintenance and differentiation of hematopoietic stem and progenitor cells

    Hematopoietic stem and progenitor cells (HSPCs) represent the lifelong source of all blood cells and continuously regenerate the hematopoietic system through differentiation and self-renewal. The process of di...

    Daniel Ewerth, Stefanie Kreutmair, Andrea Schmidts… in Cellular and Molecular Life Sciences (2019)

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    Protocol

    The Use of SNAP Labeling to Study Cell Cycle Oscillatory Proteins

    Tightly controlled degradation of specific regulatory proteins is crucial for transitioning to the next cell cycle phase, ensuring precise DNA replication and an equal distribution of chromosomes to provide ge...

    Christine Greil, Marie Follo, Monika Engelhardt, Ralph Wäsch in Cell Cycle Oscillators (2016)