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The Multifaceted Roles of B Cells in Solid Tumors: Emerging Treatment Opportunities

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  1. Article

    Open Access

    Tumor-B-cell interactions promote isotype switching to an immunosuppressive IgG4 antibody response through upregulation of IL-10 in triple negative breast cancers

    Triple negative breast cancer (TNBC) is an aggressive breast cancer for which there is currently no targeted therapy. Tumor-infiltrating B-cells (TIB) have been observed in tumor tissues of TNBC patients, but ...

    Nicole J. Toney, Lynn M. Opdenaker, Kader Cicek… in Journal of Translational Medicine (2022)

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  2. Article

    Open Access

    In vitro migration of cytotoxic T lymphocyte derived from a colon carcinoma patient is dependent on CCL2 and CCR2

    Infiltration of colorectal carcinomas (CRC) with T-cells has been associated with good prognosis. There are some indications that chemokines could be involved in T-cell infiltration of tumors. Selective modula...

    Klara Berencsi, Pyapalli Rani, Tianqian Zhang… in Journal of Translational Medicine (2011)

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  3. Article

    Open Access

    CD8+, HLA-unrestricted, cytotoxic T-lymphocyte line against malignant melanoma

    A CD8+ cytotoxic T lymphocyte (CTL) line was derived from the peripheral blood mononuclear cells of a patient with primary melanoma. The CD8+ CTL line specifically lysed the autologous primary melanoma cells and ...

    Rajasekharan Somasundaram, Laura Caputo, DuPont Guerry… in Journal of Translational Medicine (2005)

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