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Article
Open AccessCerebellar location may predict an unfavourable prognosis in paediatric high-grade glioma
High-grade glioma (HGG) of the cerebellum accounts for only 5% of paediatric HGG. Since little is known about these tumours, the present study aimed at their further characterisation.
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Article
Open AccessSecondary dissemination in children with high-grade malignant gliomas and diffuse intrinsic pontine gliomas
In children, treatment regimen for high-grade gliomas (HGG) and diffuse intrinsic pontine gliomas (DIPG) are generally not stratified according to disease stage. The hypothesis was that secondary disseminating...
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Article
Open AccessRadiation induced CNS toxicity – molecular and cellular mechanisms
Radiotherapy of tumours proximal to normal CNS structures is limited by the sensitivity of the normal tissue. Prior to the development of prophylactic strategies or treatment protocols a detailed understanding...