23 Result(s)

Article

40^th EASD Annual Meeting of the European Association for the Study of Diabetes

M. Veitenhansl, K. Stegner, F.-X. Hierl, C. Dieterle, H. Feldmeier, B. Gutt… in Diabetologia (2004)

Article

CTGF (IGFBP-rP2) is specifically expressed in malignant lymphoblasts of patients with acute lymphoblastic leukaemia (ALL)

Connective tissue growth factor (CTGF) is a major chemotactic and mitogenic factor for connective tissue cells. The amino acid sequence shares an overall 28–38% identity to IGFBPs and contains critical conserv...

P Vorwerk, H Wex, B Hohmann, Y Oh, R G Rosenfeld, U Mittler in British Journal of Cancer (2000)

Article

The Role of Insulin Sensitivity (S_I and IGFBP-1 and 3 in the hyperandrogenism (HA) of Black and Hispanic (B/H) girls with Premature Adrenarche (PA). • 425

P M Vuguin, E Wasserman, B Linder, E Oppenheimer, P Saenger… in Pediatric Research (1997)

Article

INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 (IGFBP-3) CONCENTRATION IN CEREBROSPINAL FLUID (CSF) OF CHILDREN WITH BRAIN TUMORS OR LEUKEMIA

The major IGFBPs in CSF are IGFBP-2 and IGFBP-4. whereas IGFBP-3 is a minor component in CSF of healthy subjects. We investigated IGFBP-3 levels in CSF from patients with brain tumors, leukemia or meningitis. ...

H L Müller, Y Oh, S E Gargosky, R L Ilintz, R G Rosenfeld in Pediatric Research (1993)

Article

MATERNAL HYPOXIA AS A MODEL FOR INTRA-UTERINE GROWTH RETARDATION (IUGR): EFFECTS ON INSULIN-LIKE GROWTH FACTORS AND THEIR BINDING PROTEINS

Evidence suggests that IGFs and their binding proteins play a role in fetal growth but more knowledge of their regulation is essential. We examined the expression of IGFs and their binding proteins in experime...

P J Tapanainen, P Bang, K Wilson, H Vreman, R G Rosenfeld in Pediatric Research (1993)

Article

SIX YEAR DATA OF CARBOHYDRATE TOLERANCE IN TURNER SYNDROME TREATED WITH GROWTH HORMONE AND OXANDROLONE

The increased incidence of glucose intolerance in Turner syndrome leads to an abnormal GTT in 30-60% of adult women. Since currently explored therapies to increase adult height may impair carbohydrate metaboli...

M Almaguer, P Saenger, J Frane, D Wilson, R G Rosenfeld in Pediatric Research (1993)

Article

THERAPEUTIC RESPONSE TO RECOMBINANT IGF-1 IN THIRTY TWO PATIENTS WITH GROWTH HORMONE INSENSITIVITY

30 patients with GH insensitivity syndrome (GHIS) (Laron syndrome) and 2 patients with GH gene deletion were included in a multicentre trial of recombinant human IGF-1 (rhIGF-1). The GHIS patients, from 9 Euro...

M O Savage, P Wilton, M B Ranke, P G Chatelain, W F Blum… in Pediatric Research (1993)

Article

IS IMMUNOREACTIVE IGFBP-3 IN THE URINE AN INDICATOR OF GROWTH HORMONE DEFICIENCY (GHD)?

The insulin-like growth factors (IGF) arc potent polypeptide mitogens that are carried in the blood, primarily by a GH-dependent protein, IGF binding protein-3 (IGFBP-3). This IGFBP can be fragmented by IGFBP-...

S E Gargosky, K F Wilson, I I Anhalt, M Macgillivray, R G Rosenfeld in Pediatric Research (1993)

Article

TREATMENT OF ADOLESCENT MALES WITH CONSTITUTIONAL DELAY OF GROWTH AND PUBERTY (CDGP) WITH SUBLINGUAL TESTOSTERONE (SL-T) COMPLEXED WITH HYDROXYPROPYL-β-CYCLODEXTRIN (HPBCD)

We investigated the pharmacokinetics and the effects on sexual maturation and growth of HPBCD complexed SL-T in five prepubertal males aged 14-17 years with CDGP. Patients were treated with 2.5 mg SL testoster...

P Cohen, D Brown, R Dudley, R G Rosenfeld in Pediatric Research (1993)

Article

CHARACTERIZATION AND REGULATION OF IGFBP-4 IN CULTURED MOUSE LEYDIG CELLS (TM-3)

The characterization and regulation of IGFBPs in TM-3 cells was performed. Western Ligand blots of conditioned media(CM) demonstrated the presence of 24 and 28 kDa bands as major IGFBPs, and 40 and 44 kDa as m...

T Hasegawa, P Cohen, P J Fielder, Y Hasegawa, R G Rosenfeld in Pediatric Research (1993)

Article

FIRST YEAR RESULTS Or A RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF LOW DOSE ETHINYL ESTRADIOL FOR FEMINIZATION DURING GROWTH HORMONE THERAPY FOR TURNER SYNDROME

The appropriate age to initiate estrogen replacement therapy in adolescents with Turner syndrome (TS) is uncertain due to the potential for a deleterious effect on skeletal maturation and final height. We repo...

E K Neelv, R G Rosenfeld in Pediatric Research (1993)

Article

LACK OF 150kDa TERNARY COMPLEX FORMATION IN SERUM FROM THE HUMAN FETUS IN UTERO: INCREASED BIOAVAILABILITY OF CIRCULATING IGF-1

IGF-I has been proposed to be an important endocrine growth factor in human fetal growth. We have determined IGF-I concentrations in acid chromalographed serum obtained in utero from 34 human fetuses of Rhesus...

P Bang, R G Rosenfeld, M Stangenberg, M Westgren in Pediatric Research (1993)

Article

CHANGES IN BODY AND BONE COMPOSITION IN ADOLESCENT GROWTH HORMONE RECEPTOR DEFICIENT (GHRD) PATIENTS RECEIVING rhIGF-I AND A GnRH ANALOG

We observed the body and bone composition changes in two adolescent GHRD patients receiving 120 ug/g of rhIGF-I twice daily sc. A GnRH analog was administered im once monthly. LHRH testing demonstrated a blunt...

J Guevara-Aguirre, O Vasconez, V Martinez, A L Martinez, Z Moreno… in Pediatric Research (1993)

Article

THE DIFFERENTIAL EXPRESSION OF INSULIN-LIKE GROWTH FACTOR mRNA IN TWO RAT TUMOR CELL LINES

Buffalo Rat Liver 3A (BRL) and 18, 54-SF cells are two rat tumor cell lines which have been maintained continuously in serum-free media. Both cell lines secrete rat IGF-II (>50ng/ml in three day conditioned me...

Philip M James, M L Cleary, A Hoffman, B L Hintz, R G Rosenfeld in Pediatric Research (1987)

Article

HEIGHT AND INTELLECTUAL DEVELOPMENT

We analyzed data from the National Health Examination Survey (Cycle III), a representative sample of non-institutionalized US youth (3545 males (M), 3223 females (F), 12-17 yr of age), to examine the relations...

D M Wilson, P M Duke, S M Dornbusch, P L Ritter, J M Carlsmith… in Pediatric Research (1984)