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  1. Article

    Open Access

    Melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug

    Melatonin, originally discovered as a hormone of the pineal gland, is also produced in other organs and represents, additionally, a normal food constituent found in yeast and plant material, which can influenc...

    Rüdiger Hardeland, SR Pandi-Perumal in Nutrition & Metabolism (2005)

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    Article

    Drug Insight: the use of melatonergic agonists for the treatment of insomnia—focus on ramelteon

    Melatonin has been used successfully to treat insomnia, but has not received regulatory approval by the FDA because it can be sold freely as a food supplement. This has prompted a search by pharmaceutical comp...

    Seithikurippu R Pandi-Perumal… in Nature Clinical Practice Neurology (2007)

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    Article

    Ramelteon: a review of its therapeutic potential in sleep disorders

    Ramelteon is a tricyclic synthetic analog of melatonin that acts specifically on MT1 and MT2 melatonin receptors. Ramelteon’s half-life is longer than that of melatonin, being metabolized in the body to four main...

    Seithikurippu R. Pandi-Perumal, Venkatramanujam Srinivasan… in Advances in Therapy (2009)

  4. Article

    Open Access

    Measurement of melatonin in body fluids: Standards, protocols and procedures

    The circadian rhythm of melatonin in saliva or plasma, or of the melatonin metabolite 6-sulfatoxymelatonin (a6MTs) in urine, is a defining feature of suprachiasmatic nucleus (SCN) function, the body’s endogeno...

    Eduardo Alves de Almeida, Paolo Di Mascio, Tatsuo Harumi… in Child's Nervous System (2011)

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