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  1. Article

    Open Access

    Inducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis

    Up to one person in a population of 10,000 is diagnosed once in lifetime with an encephalitis, in 50–70% of unknown origin. Recognized causes amount to 20–50% viral infections. Approximately one third of affec...

    Justus B. H. Wilke, Martin Hindermann… in Acta Neuropathologica Communications (2021)

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  2. No Access

    Article

    Melatonergic Sleep Promotion: Fundamental Chronobiological Issues Concerning Sleep Onset and Maintenance, Dose and Duration of Action

    This review summarizes the conditions under which sleep promotion by melatonin or other melatonergic drugs can be successfully achieved or not. Importantly, the chronobiological rules are outlined which have t...

    Rüdiger Hardeland in Sleep and Vigilance (2018)

  3. No Access

    Article

    Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

    The pineal product melatonin has remarkable antioxidant properties. It is secreted during darkness and plays a key role in various physiological responses including regulation of circadian rhythms, sleep homeo...

    Seithikurippu R. Pandi-Perumal, Ahmed S. BaHammam… in Neurotoxicity Research (2013)