5 Result(s)
within
Rüdiger Hardeland
Biomedicine
English
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Article
Open AccessAddressing the ‘hypoxia paradox’ in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues
Since fall 2019, SARS-CoV-2 spread world-wide, causing a major pandemic with estimated ~ 220 million subjects affected as of September 2021. Severe COVID-19 is associated with multiple organ failure, particula...
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Article
Open AccessInducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis
Up to one person in a population of 10,000 is diagnosed once in lifetime with an encephalitis, in 50–70% of unknown origin. Recognized causes amount to 20–50% viral infections. Approximately one third of affec...
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Article
Melatonergic Sleep Promotion: Fundamental Chronobiological Issues Concerning Sleep Onset and Maintenance, Dose and Duration of Action
This review summarizes the conditions under which sleep promotion by melatonin or other melatonergic drugs can be successfully achieved or not. Importantly, the chronobiological rules are outlined which have t...
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Chapter
Melatonin in Healthy Aging and Longevity
Melatonin is a regulator of the circadian multioscillator system. It transmits the information ‘darkness’, contributes to internal and external alignment of rhythms and, presumably via sirtuin-1, to high ampli...
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Article
Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes
The pineal product melatonin has remarkable antioxidant properties. It is secreted during darkness and plays a key role in various physiological responses including regulation of circadian rhythms, sleep homeo...
