9 Result(s)

Article

Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma

Neuroblastoma currently has poor prognosis, therefore we proposed a new strategy by targeting neuroblastoma with genetically engineered anaerobic Salmonella (Sal-YB1).

Zhu-Ling Guo, Bin Yu, Bo-Tao Ning, Shing Chan… in Journal of Hematology & Oncology (2015)

Article

A phase 1, open-label study of LCAR-B38M, a chimeric antigen receptor T cell therapy directed against B cell maturation antigen, in patients with relapsed or refractory multiple myeloma

Chimeric antigen receptor (CAR) T cell therapy has demonstrated proven efficacy in some hematologic cancers. We evaluated the safety and efficacy of LCAR-B38M, a dual epitope-binding CAR T cell therapy directe...

Wan-Hong Zhao, Jie Liu, Bai-Yan Wang, Yin-**a Chen… in Journal of Hematology & Oncology (2018)

Article

Choroid plexus tumours on MRI: similarities and distinctions in different grades

The therapeutic planning varies for different grades of choroid plexus tumours (CPTs). The aim of this study was to define the similarities and distinctions among MRIs for different grades of CPTs, providing m...

Huan Lin, ** Leng, Chun-hong Qin, Yong-xing Du, Wen-sheng Wang… in Cancer Imaging (2019)

Article

Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma

Clinically, the median survival in patients with metastatic renal cell carcinoma (RCC) was only 6–12 months and a 5-year survival rate of less than 20%. Therefore, an in-depth study of the molecular mechanisms...

Qian Zhu, Ai-Lin Zhong, Hao Hu, **g-**g Zhao… in Journal of Hematology & Oncology (2020)

Article

Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice

The lung is the prophylaxis target against SARS-CoV-2 infection, and neutralizing antibodies are a leading class of biological products against various infectious viral pathogen. In this study, we develop a sa...

Jia-Qi Li, Zhe-Rui Zhang, Hong-Qing Zhang… in Signal Transduction and Targeted Therapy (2021)

Article

Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters

Ya-Nan Zhang, Zhe-Rui Zhang, Hong-Qing Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Induction immune-checkpoint inhibitors for resectable oncogene-mutant NSCLC: A multicenter pooled analysis

Despite limited efficacy of immunotherapy for advanced non-small-cell lung cancer (NSCLC) with driver mutations, whether neoadjuvant immunotherapy could be clinically valuable in those patients warrants furthe...

Chao Zhang, Hua-Fei Chen, Shi Yan, Lin Wu, Li-Xu Yan… in npj Precision Oncology (2022)

Article

Application of metabolomics in urolithiasis: the discovery and usage of succinate

Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone events. It has been shown that the occurrence of calcium oxalate monohydrate (COM) during stone formation is regu...

**u-zhen Zhang, **ong-xin Lei, Yan-lin Jiang… in Signal Transduction and Targeted Therapy (2023)

Article

Correction: Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma

Qian Zhu, Ai-Lin Zhong, Hao Hu, **g-**g Zhao… in Journal of Hematology & Oncology (2023)