73 Result(s)

Article

Distinct characteristics of the gut virome in patients with osteoarthritis and gouty arthritis

The gut microbiota and its metabolites play crucial roles in pathogenesis of arthritis, highlighting gut microbiota as a promising avenue for modulating autoimmunity. However, the characterization of the gut v...

Chang-Ming Chen, Qiu-Long Yan, Ruo-Chun Guo, Fang Tang… in Journal of Translational Medicine (2024)

Article

Effect of scutellarin on BV-2 microglial-mediated apoptosis in PC12 cells via JAK2/STAT3 signalling pathway

Previous studies have shown that scutellarin inhibits the excessive activation of microglia, reduces neuronal apoptosis, and exerts neuroprotective effects. However, whether scutellarin regulates activated mic...

Zhao-Da Duan, Li-Yang Zheng, Qiu-Ye Jia, Hao-Lun Chen, Dong-Yao Xu… in Scientific Reports (2024)

Article

Adjuvants for cancer mRNA vaccines in the era of nanotechnology: strategies, applications, and future directions

Research into mRNA vaccines is advancing rapidly, with proven efficacy against coronavirus disease 2019 and promising therapeutic potential against a variety of solid tumors. Adjuvants, critical components of ...

Lei-Ming Cao, Yi-Fu Yu, Zi-Zhan Li, Nian-Nian Zhong… in Journal of Nanobiotechnology (2024)

Article

Prevalence and genetic diversity of Anaplasma and Ehrlichia in ticks and domesticated animals in Suizhou County, Hubei Province, China

Anaplasma and Ehrlichia are tick-borne bacterial pathogens that cause anaplasmoses and ehrlichioses in humans and animals. In this study, we examined the prevalence of Anaplasma and Ehrlichia species in ticks and...

Ju Tang, Jiao Xu, **ao-hui Liu, Fang-zhi Lv, Qiu-ju Yao… in Scientific Reports (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Effect of early peri-operative arterial lactate concentration level ratios on post-hepatectomy liver failure

Post-hepatectomy liver failure (PHLF) is a serious complication after hepatectomy and a major cause of death. The current criteria for PHLF diagnosis (ISGLS consensus) require laboratory data of elevated INR l...

Dong-Dong Wang, Meng-Meng Dong, Ya-Ming **e, Fei-Qi Xu, Tian-Wei Fu… in Discover Oncology (2024)

Article

The role of nutrition in analysis of risk factors and short-term outcomes for late-onset necrotizing enterocolitis among very preterm infants: a nationwide, multicenter study in China

Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades,...

Kun-Yao Hong, Yao Zhu, Fan Wu, Jian Mao, Ling Liu, Rong Zhang… in BMC Pediatrics (2024)

Article

Electron scale coherent structure as micro accelerator in the Earth’s magnetosheath

Turbulent energy dissipation is a fundamental process in plasma physics that has not been settled. It is generally believed that the turbulent energy is dissipated at electron scales leading to electron energi...

Zi-Kang **e, Qiu-Gang Zong, Chao Yue, Xu-Zhi Zhou, Zhi-Yang Liu… in Nature Communications (2024)

Article

Tri©DB: an integrated platform of knowledgebase and reporting system for cancer precision medicine

With the development of cancer precision medicine, a huge amount of high-dimensional cancer information has rapidly accumulated regarding gene alterations, diseases, therapeutic interventions and various annot...

Wei Jiang, Peng-Ying Wang, Qi Zhou, Qiu-Tong Lin… in Journal of Translational Medicine (2023)

Article

The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology

Ample evidence has suggested the stress etiology of depression, but the underlying mechanism is not fully understood yet. Here, we report that chronic social defeat stress (CSDS) attenuates the excitatory outp...

Yu-Jun Wang, Gui-Ying Zan, Cenglin Xu, Xue-** Li, Xuelian Shu… in Nature Communications (2023)

Article

Prenylated flavonoids isolated from the twigs of Artocarpus champeden as potential activators for tobacco powdery mildew and their mode of actions

Golovinomyces cichoracearum (DC.) is the main pathogen for tobacco powdery mildew fungus disease. Its outbreaks often result in severe harvest losses for the yield and quality of tobacco. Artocarpus champeden is ...

Qiu-Fen Hu, Sui Yao, Yue-Yu Ma… in Chemical and Biological Technologies in Ag… (2023)

Article

Incidence of periprosthetic joint infection after primary total hip arthroplasty is underestimated: a synthesis of meta-analysis and bibliometric analysis

The American Musculoskeletal Society updated the diagnostic criteria for periprosthetic joint infection (PJI) in 2011 and 2018. However, the overall incidence of PJI since the introduction of these new standar...

Zi-Jun Zeng, Fang-Ming Yao, Wei He… in Journal of Orthopaedic Surgery and Research (2023)

Article

Vacuum sealing drainage to treat Fournier’s gangrene

Vacuum sealing drainage (VSD) is widely applied in complex wound repair. We aimed to compare traditional debridement and drainage and VSD in treating Fournier’s gangrene (FG).

Ju-hua Chen, Yu-bo Li, De-gang Li, **ao-mei Zeng, Qiu-yuan Yao, Jun Fu… in BMC Surgery (2023)

Article

A clinical experience-based Chinese herbal formula improves ethanol-induced drunken behavior and hepatic steatohepatitis in mice models

Bao-Gan-**ng-Jiu-Wan (BGXJW) is a clinical experience-based Chinese herbal formula. Its efficacy, pharmacological safety, targeted function, process quality, and other aspects have met the evaluation standards...

Han Gao, Zhen Li, Yao Liu, Yong-kang Zhao, Cheng Cheng, Feng Qiu… in Chinese Medicine (2023)

Article

A Cohort Study on Deficiency of ADA2 from China

Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in adenosine deaminase 2 (ADA2), has not been systemically investigat...

Guo-min Li, Xu Han, Ye Wu, Wei Wang, Hong-xia Tang… in Journal of Clinical Immunology (2023)

Article

Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3β Ser9 autophosphorylation independent of its kinase activity in non-small-cell lung cancer

Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is a major challenge for clinicians and patients with non-small cell lung cancer (NSCLC). Serine-arginine protein kinase ...

**g-Qiang Huang, Ling-**n Duan, Qiu-Yu Liu, He-Feng Li, Ao-** Hu… in Oncogene (2023)

Article

Noisy intermediate-scale quantum computers

Quantum computers have made extraordinary progress over the past decade, and significant milestones have been achieved along the path of pursuing universal fault-tolerant quantum computers. Quantum advantage, ...

Bin Cheng, **u-Hao Deng, **u Gu, Yu He, Guangchong Hu, Peihao Huang… in Frontiers of Physics (2023)

Article

Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder

The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsiste...

Yu-Dan Ding, **ao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li… in Translational Psychiatry (2022)

Article

β-Amyloid in blood neuronal-derived extracellular vesicles is elevated in cognitively normal adults at risk of Alzheimer’s disease and predicts cerebral amyloidosis

Blood biomarkers that can be used for preclinical Alzheimer’s disease (AD) diagnosis would enable trial enrollment at a time when the disease is potentially reversible. Here, we investigated plasma neuronal-de...

Tao-Ran Li, Yun-**a Yao, Xue-Yan Jiang, Qiu-Yue Dong… in Alzheimer's Research & Therapy (2022)

Article

Publisher Correction: Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial

Hai-Qiang Mai, Qiu-Yan Chen, Dong** Chen, Chaosu Hu, Kunyu Yang… in Nature Medicine (2022)