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Article
Improving RSW nugget diameter prediction method: unleashing the power of multi-fidelity neural networks and transfer learning
This research presents an innovative approach to accurately predict the nugget diameter in resistance spot welding (RSW) by leveraging machine learning and transfer learning methods. Initially, low-fidelity (L...
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Article
Open AccessDistinct characteristics of the gut virome in patients with osteoarthritis and gouty arthritis
The gut microbiota and its metabolites play crucial roles in pathogenesis of arthritis, highlighting gut microbiota as a promising avenue for modulating autoimmunity. However, the characterization of the gut v...
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Article
Open AccessEffect of scutellarin on BV-2 microglial-mediated apoptosis in PC12 cells via JAK2/STAT3 signalling pathway
Previous studies have shown that scutellarin inhibits the excessive activation of microglia, reduces neuronal apoptosis, and exerts neuroprotective effects. However, whether scutellarin regulates activated mic...
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Article
Open AccessAdjuvants for cancer mRNA vaccines in the era of nanotechnology: strategies, applications, and future directions
Research into mRNA vaccines is advancing rapidly, with proven efficacy against coronavirus disease 2019 and promising therapeutic potential against a variety of solid tumors. Adjuvants, critical components of ...
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Article
Open AccessPrevalence and genetic diversity of Anaplasma and Ehrlichia in ticks and domesticated animals in Suizhou County, Hubei Province, China
Anaplasma and Ehrlichia are tick-borne bacterial pathogens that cause anaplasmoses and ehrlichioses in humans and animals. In this study, we examined the prevalence of Anaplasma and Ehrlichia species in ticks and...
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Article
PHPB ameliorates memory deficits and reduces oxidative injury in Alzheimer’s disease mouse model by activating Nrf2 signaling pathway
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia in elderly people and substantially affects patient quality of life. Oxidative stress is considered a ke...
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Article
Prenylated Flavonoids from Desmodium caudatum and as Potential Activators for SARS-CoV-2
Two new isoprenylated flavone, 8,4′-dimethoxy-6-(4-methyl-1H-pyrrol-2-yl)-flavone (1), 8-hydroxy-4′-methoxy-6-(4-methyl-1H-pyrrol-2-yl)-flavone (2), together with seven known isoprenylated flavonoids (3–9) were i...
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Article
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages
Ulcerative colitis (UC) is associated with changed dietary habits and mainly linked with the gut microbiota dysbiosis, necroptosis of epithelial cells, and mucosal ulcerations. Liver dysfunction and abnormal l...
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Article
Elastic three-dimensional phononic topological insulators with Dirac hierarchy
Three-dimensional (3D) phononic topological insulators (TIs) featuring two-dimensional (2D) surface states and one-dimensional (1D) hinge states have opened up a new route for multi-dimensional robust wave tra...
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Article
Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
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Article
Open AccessEffect of early peri-operative arterial lactate concentration level ratios on post-hepatectomy liver failure
Post-hepatectomy liver failure (PHLF) is a serious complication after hepatectomy and a major cause of death. The current criteria for PHLF diagnosis (ISGLS consensus) require laboratory data of elevated INR l...
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Article
Open AccessThe role of nutrition in analysis of risk factors and short-term outcomes for late-onset necrotizing enterocolitis among very preterm infants: a nationwide, multicenter study in China
Necrotizing enterocolitis (NEC) is a serious gastrointestinal disease, primarily affects preterm newborns and occurs after 7 days of life (late-onset NEC, LO-NEC). Unfortunately, over the past several decades,...
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Article
**ashengella succiniciproducens gen. nov., sp. nov., a succinate-producing bacterium isolated from an anaerobic digestion tank in the family Marinilabiliaceae of the order Bacteroidales
A strictly anaerobic, motile bacterium, designated as strain Ai-910T, was isolated from the sludge of an anaerobic digestion tank in China. Cells were Gram-stain-negative rods. Optimal growth was observed at 38 °...
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Article
Fluorometric Assay of Tyrosinase and Atrazine Based on the Use of Carbon Dots and the Inhibition of Tyrosinase Activity
Sensitive and convenient strategy of tyrosinase (TYR) and its inhibitor atrazine is in pressing demand for essential research as well as pragmatic application. In this work, an exquisite label-free fluorometri...
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Article
Embryo Transfer Strategies for Women with Recurrent Implantation Failure During the Frozen-thawed Embryo Transfer Cycles: Sequential Embryo Transfer or Double-blastocyst Transfer?
Both sequential embryo transfer (SeET) and double-blastocyst transfer (DBT) can serve as embryo transfer strategies for women with recurrent implantation failure (RIF). This study aims to compare the effects o...
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Article
Clinical risk factors and prognostic model for patients with bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation
Bronchiolitis obliterans syndrome (BOS) is a common and potentially devastating noninfectious pulmonary complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Currently, predictive ...
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Article
Open AccessElectron scale coherent structure as micro accelerator in the Earth’s magnetosheath
Turbulent energy dissipation is a fundamental process in plasma physics that has not been settled. It is generally believed that the turbulent energy is dissipated at electron scales leading to electron energi...
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Chapter and Conference Paper
Research and Application of Seismic Acquisition in Complex Surface Areas of Southwest Sichuan
The southeast Sichuan Basin is rich in natural gas reserves, with 11 sets of conventional gas and unconventional gas reservoirs. However, the improvement of seismic data quality in this area is restricted by m...
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Article
Efficacy and Safety of Different Doses of Rivaroxaban and Risk Factors for Bleeding in Elderly Patients with Venous Thromboembolism: A Real-World, Multicenter, Observational, Cohort Study
Venous thromboembolism (VTE) consists of deep vein thrombosis (DVT) and pulmonary embolism (PE). Rivaroxaban is a direct oral anticoagulant (DOAC) inhibiting activated coagulation factor X (FXa), and exerts se...
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Article
Open AccessTri©DB: an integrated platform of knowledgebase and reporting system for cancer precision medicine
With the development of cancer precision medicine, a huge amount of high-dimensional cancer information has rapidly accumulated regarding gene alterations, diseases, therapeutic interventions and various annot...
