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  1. Article

    Open Access

    Segregation of morphogenetic regulatory function of Shox2 from its cell fate guardian role in sinoatrial node development

    Shox2 plays a vital role in the morphogenesis and physiological function of the sinoatrial node (SAN), the primary cardiac pacemaker, manifested by the formation of a hypoplastic SAN and failed differentiation of...

    Hua Li, Qinghuang Tang, Tianfang Yang, Zhengsen Wang, Dainan Li in Communications Biology (2024)

  2. Article

    Open Access

    Lactate promotes the growth of patient-derived organoids from hepatopancreatobiliary cancers via ENO1/HIF1α pathway and does not affect their drug sensitivities

    The long culture duration of patient-derived organoids (PDOs) have severely limited their clinical applications. The aim of this study was to determine the effect of lactate supplementation on the growth, gene...

    Zhiwei Wang, Yuanquan Yu, Peiyao Wu, Qinghuang Ye, Yinghao Guo in Cell Death Discovery (2022)

  3. No Access

    Article

    Characteristics of butanol fermentation by a low-acid-producing Clostridium acetobutylicum B18

    Fermentation characteristics of Clostridium acetobutylicum B18 were studied in batch experiments with and without pH control. This strain is shown to be potentially useful in simultaneous acetone-butanol-ethanol ...

    Chang-Ho Park, Qinghuang Geng, Palmer Rogers in Applied Microbiology and Biotechnology (1993)

  4. No Access

    Article

    Controlled-ph batch butanol-acetone fermentation by low acid producing Clostridium acetobutylicum B18

    C. acetobutylicum B18 produced a large amount of butanol over a wide range of pH (4.5–6.0). At pH 6.0 fermentation and cell growth were most active at pH 6.0, and the highest values of glucose consumption rate (...

    Qinghuang Geng, Chang-Ho Park in Biotechnology Letters (1993)