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Article
Open AccessSegregation of morphogenetic regulatory function of Shox2 from its cell fate guardian role in sinoatrial node development
Shox2 plays a vital role in the morphogenesis and physiological function of the sinoatrial node (SAN), the primary cardiac pacemaker, manifested by the formation of a hypoplastic SAN and failed differentiation of...
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Article
Open AccessLactate promotes the growth of patient-derived organoids from hepatopancreatobiliary cancers via ENO1/HIF1α pathway and does not affect their drug sensitivities
The long culture duration of patient-derived organoids (PDOs) have severely limited their clinical applications. The aim of this study was to determine the effect of lactate supplementation on the growth, gene...
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Article
Characteristics of butanol fermentation by a low-acid-producing Clostridium acetobutylicum B18
Fermentation characteristics of Clostridium acetobutylicum B18 were studied in batch experiments with and without pH control. This strain is shown to be potentially useful in simultaneous acetone-butanol-ethanol ...
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Article
Controlled-ph batch butanol-acetone fermentation by low acid producing Clostridium acetobutylicum B18
C. acetobutylicum B18 produced a large amount of butanol over a wide range of pH (4.5–6.0). At pH 6.0 fermentation and cell growth were most active at pH 6.0, and the highest values of glucose consumption rate (...