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Article
Open AccessPenpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study
Penpulimab is an anti-programmed cell death-1 (PD-1) IgG1 antibody with no Fc gamma receptor (FcγR) binding activity, and thus theoretically reduced immune-related adverse events (irAEs) while maintaining effi...
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Article
Open AccessEffects of metformin on the glucose regulation, lipid levels and gut microbiota in high-fat diet with streptozotocin induced type 2 diabetes mellitus rats
Metformin, an anti-diabetic drug, regulates blood glucose by affecting gut microbiotas. However, the potential mechanism underlying this effect remains unclear. This study aimed to evaluate the effect of metfo...
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Article
Open AccessComparison of the clinical characteristics in parents and their children in a series of family clustered Mycoplasma pneumoniae infections
Mycoplasma pneumoniae infections have increased in China recently, causing some evidence of familial clustering. The purpose of this study was to compare the clinical features of parents and children in cases of...
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Article
Open AccessClinical courses and outcomes of COVID-19 associated pulmonary aspergillosis in 168 patients with the SARS-CoV-2 omicron variant
We aimed to analyze the clinical features of COVID-19-associated pulmonary aspergillosis (CAPA) during the SARS-CoV-2 Omicron variant pandemic and to reveal the risk factors for CAPA and death.
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Article
Open AccessTwo novel mutations within FREM1 gene in patients with bifid nose
Bifid nose is a rare congenital deformity and the etiology is unknown. The purpose of this study was to report genetic variation in family of patients with bifid nose.
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Article
Effect of obstructive sleep apnea on semen quality
Obstructive sleep apnea (OSA) has several notable complications such as hypertension and diabetes. Studies have also shown that OSA is associated with erectile dysfunction and reduced androgen levels. However,...
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Article
Open AccessAe index is an independent predictor of kidney stone recurrence in overweight and obese patients
Finding some convenient and economical indicators to initially screen overweight and obese patients at high risk of kidney stone recurrence can help them prevent stone recurrence with lower medical cost. The p...
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Article
Open AccessCorrection: The association between air pollution and the daily hospital visits for atrial fibrillation recorded by ECG: a case-crossover study
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Article
NREM sleep loss increases neurofilament light chain levels in APP/PS1 and C57BL/6 J mice
Sleep disturbances exacerbate the progression of Alzheimer’s disease (AD), but disturbances of non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep may have different effects. Neurofilament l...
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Open AccessThe association between air pollution and the daily hospital visits for atrial fibrillation recorded by ECG: a case-crossover study
The relationship between air pollution and atrial fibrillation (AF) recorded by electrocardiograph (ECG) has not yet been illustrated which worsens AF precaution and treatment. This research evaluated the asso...
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Article
Open AccessDiagnostic value of a nanopore sequencing assay of bronchoalveolar lavage fluid in pulmonary tuberculosis
To determine the diagnostic accuracy of a nanopore sequencing assay of PCR products from a M. tuberculosis complex-specific region for testing of bronchoalveolar lavage fluid (BALF) samples or sputum samples f...
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Open AccessBile acid predicts congenital portosystemic venous shunt in patients with pulmonary arterial hypertension
The etiology of pulmonary arterial hypertension (PAH) is complex, especially the investigation of rare pathogeny is difficult. Congenital portosystemic venous shunt (CPSS) is a rare congenital anomaly in which...
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Article
Open AccessAssociation of circulating tumor cell-white blood cell clusters with survival outcomes in patients with colorectal cancer after curative intent surgery
The analysis of circulating tumor cell-associated white blood cell (CTC-WBC) clusters represented the progress in the liquid biopsy of malignant tumors, however, related research in patients with colorectal ca...
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Open AccessSurgical Strategies for Eyelid Defect Reconstruction: A Review on Principles and Techniques
Reconstruction of eyelid defects, especially the posterior lamella, remains challenging because of its anatomical complexity, functional considerations, and aesthetic concerns. The goals of eyelid reconstructi...
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Article
Open AccessDistribution and drug sensitivity of pathogenic bacteria in diabetic foot ulcer patients with necrotizing fasciitis at a diabetic foot center in China
Diabetic foot ulcer is one of the major complications for patients with diabetes, and has become an important cause of non-traumatic amputation. Necrotizing fasciitis is a life-threatening soft-tissue infectio...
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Article
Open AccessMicroRNA-455-3p regulates proliferation and osteoclast differentiation of RAW264.7 cells by targeting PTEN
Macrophages are one of the important cells in immune system. In this article, we aim to explore the regulatory role of miR-455-3p on proliferation and osteoblast differentiation of RAW264.7 cells.
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Adjunctive interleukin-2 for the treatment of drug-susceptible tuberculosis: a randomized control trial in China
Evaluation of the efficacy and safety of IL-2 in the treatment of drug-susceptible tuberculosis.
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Article
Open AccessThe impact of cardiomotor rehabilitation on endothelial function in elderly patients with chronic heart failure
To explore the effects of cardiac exercise rehabilitation on peripheral blood endothelial progenitor cells (EPC) in elderly patients with chronic heart failure.
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Article
Efficacy and Safety of the Biosimilar IBI301 Plus Standard CHOP (I-CHOP) in Comparison With Rituximab Plus CHOP (R-CHOP) in Patients with Previously Untreated Diffuse Large B-Cell Lymphoma (DLBCL): A Randomized, Double-Blind, Parallel-Group, Phase 3 Trial
Patients with diffuse large B-cell lymphoma (DLBCL) have limited access to rituximab. IBI301 is a recombinant chimeric murine/human anti-CD20 monoclonal antibody and is a candidate biosimilar to rituximab. Th...
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Article
Residents’ Willingness to Maintain Contracts with Family Doctors: a Cross-sectional Study in China
Most previous studies of the family doctor contract services (FDCS) evaluated its quality by using residents’ signing rates, awareness, and satisfaction. We hypothesize that renewal willingness could be anothe...