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  1. No Access

    Article

    Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function

    Activation of receptor protein kinases is prevalent in various cancers with unknown impact on ferroptosis. Here we demonstrated that AKT activated by insulin-like growth factor 1 receptor signalling phosphoryl...

    Ke Wu, Meisi Yan, Tong Liu, Zheng Wang, Yuran Duan, Yan **a… in Nature Cell Biology (2023)

  2. No Access

    Article

    Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth

    Impairment of the circadian clock is linked to cancer development. However, whether the circadian clock is modulated by oncogenic receptor tyrosine kinases remains unclear. Here we demonstrated that receptor t...

    Tong Liu, Zheng Wang, Leiguang Ye, Yuran Duan, Hongfei Jiang… in Nature Cell Biology (2023)