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Open AccesscircCDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models
Chronic wounds are a major complication in patients with diabetes. Here, we identify a therapeutic circRNA and load it into small extracellular vesicles (sEVs) to treat diabetic wounds in preclinical models. W...
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Triple-junction solar cells with cyanate in ultrawide-bandgap perovskites
Perovskite bandgap tuning without quality loss makes perovskites unique among solar absorbers, offering promising avenues for tandem solar cells1,2. However, minimizing the voltage loss when their bandgap is incr...
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Open AccessAnterior atlantoaxial motion preservation fixation technique for axis complex fractures (odontoid process with Hangman’s fractures) and technique notes
This study aims to investigate the feasibility and efficacy of anterior atlantoaxial motion preservation fixation (AMPF) in treating axis complex fractures involving the odontoid process fracture and Hangman’s...
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Integrative knowledge-based nitrogen management practices can provide positive effects on ecosystem nitrogen retention
Knowledge-based nitrogen (N) management provides better synchronization of crop N demand with N supply to enhance crop production while reducing N losses. Yet, how these N management practices contribute to re...
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Open AccessSpatial distribution characteristics and influencing factors of traditional villages in Fujian Province, China
As the historical and contemporary values of Chinese traditional villages continue to emerge and the circumstances of the times change, their preservation has a lasting and far-reaching significance in promoti...
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Open AccessEstimation and update of betweenness centrality with progressive algorithm and shortest paths approximation
Betweenness centrality is one of the key measures of the node importance in a network. However, it is computationally intractable to calculate the exact betweenness centrality of nodes in large-scale networks....
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Open AccessUltrafast Carbonized Wood of Electrode-Scaled Aligned-Porous Structure for High-Performance Lithium Batteries
The use of carbonized wood in various functional devices is attracting considerable attention due to its low cost, vertical channels, and high electrical conduction. However, the conventional carbonization met...
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Open AccessMultimodal analysis of cell-free DNA whole-methylome sequencing for cancer detection and localization
Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the performance of blood-based early cancer detection. However, integrative profiling of cfDNA methylome and fragmentome has been t...
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Open AccessAuthor Correction: Identification of recurrent USP48 and BRAF mutations in Cushing’s disease
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Open AccessWastewater-based epidemiology predicts COVID-19-induced weekly new hospital admissions in over 150 USA counties
Although the coronavirus disease (COVID-19) emergency status is easing, the COVID-19 pandemic continues to affect healthcare systems globally. It is crucial to have a reliable and population-wide prediction to...
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Open AccessDiversity-oriented synthesis of P-stereogenic and axially chiral monodentate biaryl phosphines enabled by C-P bond cleavage
Chiral monodentate biaryl phosphines (MOPs) have attracted intense attention as chiral ligands over the past decades. However, the creation of structurally diverse chiral MOPs with both P- and axial chirality is ...
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Open AccessExogenous AMPA downregulates gamma-frequency network oscillation in CA3 of rat hippocampal slices
Pharmacologically-induced persistent hippocampal γ oscillation in area CA3 requires activation of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs). However, we demonstrated that exogenous AM...
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Open AccessPublisher Correction: Epigenetic landscape reveals MECOM as an endothelial lineage regulator
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Open AccessAssociation between serum creatinine and type 2 diabetes in the Chinese population: a retrospective cohort study
The relationship between serum creatinine and type 2 diabetes is limited. We aimed to investigate the association of baseline serum creatinine and new-onset type 2 diabetes in Chinese population. This retrospe...
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Open AccessEpigenetic landscape reveals MECOM as an endothelial lineage regulator
A comprehensive understanding of endothelial cell lineage specification will advance cardiovascular regenerative medicine. Recent studies found that unique epigenetic signatures preferentially regulate cell id...
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Article
Open AccessIntegrated opposite charge grafting induced ionic-junction fiber
The emergence of ionic-junction devices has attracted growing interests due to the potential of serving as signal transmission and translation media between electronic devices and biological systems using ions...
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Open AccessContinuously processing waste lignin into high-value carbon nanotube fibers
High value utilization of renewable biomass materials is of great significance to the sustainable development of human beings. For example, because biomass contains large amounts of carbon, they are ideal cand...
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Open AccessUltrahigh resistance of hexagonal boron nitride to mineral scale formation
Formation of mineral scale on a material surface has profound impact on a wide range of natural processes as well as industrial applications. However, how specific material surface characteristics affect the m...
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Open AccessObservations of boundary layer wind and turbulence of a landfalling tropical cyclone
This study investigates the atmospheric boundary layer structure based on multiple-level tower observations with a height of 350 m during the landfall of Super Typhoon Mangkhut (2018). Results show a layer of ...
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Open AccessAdipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling
Aberrant amino acid metabolism is a common event in obesity. Particularly, subjects with obesity are characterized by the excessive plasma kynurenine (Kyn). However, the primary source of Kyn and its impact on...