22 Result(s)
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Open AccessFollow-up study to explore the relationship between Neutrophil to lymphocyte ratio and impaired fasting glucose—using the group-based trajectory modeling
Previous studies have indicated a link between neutrophil to lymphocyte ratio (NLR) and impaired fasting glucose (IFG), but the findings have been disputed. By conducting a real-world follow-up study, we can m...
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Open AccessComprehensive analysis of immunogenic cell death-related gene and construction of prediction model based on WGCNA and multiple machine learning in severe COVID-19
The death of coronavirus disease 2019 (COVID-19) is primarily due to from critically ill patients, especially from ARDS complications caused by SARS-CoV-2. Therefore, it is essential to contribute an in-depth ...
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Open AccessMatrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions
Although emerging evidence indicates that alterations in proteins within nuclear compartments elicit changes in chromosomal architecture and differentiation, the underlying mechanisms are not well understood. ...
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Open AccessAuthor Correction: The bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair
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Open AccessRNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
BRCA1-BARD1 heterodimers act in multiple steps during homologous recombination (HR) to ensure the prompt repair of DNA double strand breaks. Dysfunction of the BRCA1 pathway enhances the therapeutic efficiency...
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Open AccessInner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture
Precise control of gene expression during differentiation relies on the interplay of chromatin and nuclear structure. Despite an established contribution of nuclear membrane proteins to developmental gene regu...
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Open AccessSynergistic effects of bast fiber seedling film and nano-silicon fertilizer to increase the lodging resistance and yield of rice
The use of bast fiber film can improve rice seedling quality, and nano-silicon fertilizer can increase rice yields. This study aimed to compare the effects of using bast fiber film, nano-silicon fertilizer, an...
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Open AccessReciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling
The RNA-sensing pathway contributes to type I interferon (IFN) production induced by DNA damaging agents. However, the potential involvement of RNA sensors in DNA repair is unknown. Here, we found that retinoi...
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Open AccessEffectiveness of hysteroscopic resection of a uterine caesarean niche can be predicted: a prospective cohort study
This study aimed to develop and validate a model for the preoperative prediction of the effectiveness of hysteroscopic resection of a uterine cesarean niche in patients with postmenstrual spotting. The predict...
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Open AccessChemical synthesis of glycans up to a 128-mer relevant to the O-antigen of Bacteroides vulgatus
Glycans are involved in various life processes and represent critical targets of biomedical developments. Nevertheless, the accessibility to long glycans with precise structures remains challenging. Here we re...
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Open AccessThe bromodomain containing protein BRD-9 orchestrates RAD51–RAD54 complex formation and regulates homologous recombination-mediated repair
Homologous recombination (HR) is important for error-free DNA double strand break repair and maintenance of genomic stability. However, upregulated HR is also used by cancer cells to promote therapeutic resist...
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Open AccessThe expression pattern of OsDim1 in rice and its proposed function
Development of plant tissues is dependent on numerous factors, including hormone activity, signaling, cell division, and elongation. In plants, Defective Entry into Mitosis 1 (Dim1) homologs are recognized as piv...
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Open AccessAccurate estimation of cell-type composition from gene expression data
The rapid development of single-cell transcriptomic technologies has helped uncover the cellular heterogeneity within cell populations. However, bulk RNA-seq continues to be the main workhorse for quantifying ...
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Open AccessClinical application of noninvasive prenatal screening for sex chromosome aneuploidies in 50,301 pregnancies: initial experience in a Chinese hospital
To evaluate the clinical performance of noninvasive prenatal screening (NIPS) for fetal sex chromosome aneuploidies (SCAs), pregnant women were recruited in this retrospective observational study. The NIPS tes...
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Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+
Imaging the transcriptome in situ with high accuracy has been a major challenge in single-cell biology, which is particularly hindered by the limits of optical resolution and the density of transcripts in sing...
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Open AccessTemperature Dependence of Hourly, Daily, and Event-based Precipitation Extremes Over China
Theoretically, precipitation extremes will increase at a rate of 6–7% with temperature increasing, namely the Clausius-Clapeyron relationship. However, many gauge observations suggest a peak structure of the r...
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Open AccessIdentification of copy number variations among fetuses with ultrasound soft markers using next-generation sequencing
A prospective analysis investigating the associations between pathogenic copy number variations (pCNVs) and ultrasound soft markers (USMs) in fetuses and evaluating the clinical value of copy number variation ...
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Open AccessCalretinin Participates in Regulating Steroidogenesis by PLC-Ca2+-PKC Pathway in Leydig Cells
Calretinin, a Ca2+-binding protein, participates in many cellular events. Our previous studies found the high expression of calretinin in testicular Leydig cells. In this study, (MLTC-1 cells were infected with L...
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Open AccessColonic luminal microbiota and bacterial metabolite composition in pregnant Huanjiang mini-pigs: effects of food composition at different times of pregnancy
The gut harbours diverse and complex microbiota, which influence body health including nutrient metabolism, immune development, and protection from pathogens. Pregnancy is associated with immune and metabolic ...
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Open AccessThe association between gallstones and metabolic syndrome in urban Han Chinese: a longitudinal cohort study
The precise association between metabolic syndrome (MetS) and gallstone disease remains unclear in China. This study aimed to clarify the relationship between MetS and gallstone and evaluate whether counts of ...
