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  1. Article

    Open Access

    NGEF is a potential prognostic biomarker and could serve as an indicator for immunotherapy and chemotherapy in lung adenocarcinoma

    Neuronal guanine nucleotide exchange factor (NGEF) plays a key role in several cancers; however, its role in lung adenocarcinoma (LUAD) remains unclear. The aim of this study was to evaluate the efficacy of NG...

    **n Chen, Tao Zhang, Yan-qiu He, Ti-wei Miao, Jie Yin, Qian Ding in BMC Pulmonary Medicine (2024)

  2. No Access

    Article

    Bibliometric analysis of the 100 most-cited papers about the role of gut microbiota in irritable bowel syndrome from 2000 to 2021

    Over the last few decades, gut microbiota research has been the focus of intense research and this field has become particularly important. This research aimed to provide a quantitative evaluation of the 100 ...

    Changshan Wan, **angxu Kong, Yusheng Liao, Qiuyu Chen in Clinical and Experimental Medicine (2023)

  3. Article

    Open Access

    Signaling pathways in rheumatoid arthritis: implications for targeted therapy

    Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality of life for sufferer...

    Qian Ding, Wei Hu, Ran Wang, Qinyan Yang in Signal Transduction and Targeted Therapy (2023)

  4. Article

    Open Access

    Inhibition of p38 mitogen-activated protein kinases may attenuate scar proliferation after cleft lip surgery in rabbits via Smads signaling pathway

    Cleft lip repair surgery always results in visible scarring. It has been proved that scar formation can be reduced by inhibiting the p38 mitogen-activated protein kinases (p38MAPKs) signaling pathway. However,...

    Qian Ding, ** Yue, Ling-fa Xue, Yao-xiang Xu in European Journal of Medical Research (2022)

  5. Article

    Open Access

    STAT3-NAV2 axis as a new therapeutic target for rheumatoid arthritis via activating SSH1L/Cofilin-1 signaling pathway

    Ran Wang, Jianghong Cai, Keyuan Chen in Signal Transduction and Targeted Therapy (2022)

  6. No Access

    Article

    REC8 promotes tumor migration, invasion and angiogenesis by targeting the PKA pathway in hepatocellular carcinoma

    REC8 is a member of the cohesin family, and its abnormal activation has been detected in cancer cells. This study explored the role and possible mechanism of REC8 in hepatocellular carcinoma (HCC). A total of ...

    **g Han, Yun Bai, Jia Wang, **ao-li **e, Ai-di Li in Clinical and Experimental Medicine (2021)

  7. Article

    Open Access

    Blood flow changes in the forearm arteries after ultrasound-guided costoclavicular brachial plexus blocks: a prospective observational study

    An increase in blood flow in the forearm arteries has been reported after brachial plexus block (BPB). However, few studies have quantitatively analysed the blood flow of the forearm arteries after BPB or have...

    Yang Xu, Derong Cui, Junfeng Zhang, Qian Ding, **g Dong, Yan Wang in BMC Anesthesiology (2021)

  8. Article

    Open Access

    White, affluent, educated parents are least likely to choose HPV vaccination for their children: a cross-sectional study of the National Immunization Study – teen

    Human Papillomavirus (HPV) vaccination coverage is below national goals in the United States. Research is needed to inform strategically designed interventions that target sociodemographic groups with underuti...

    Echo L. Warner, Qian Ding, Lisa M. Pappas, Kevin Henry, Deanna Kepka in BMC Pediatrics (2017)

  9. Article

    Open Access

    Use of Prazosin for Pediatric PTSD-Associated Nightmares and Sleep Disturbances: A Retrospective Chart Review

    Youth exposed to trauma have an increased risk for develo** posttraumatic stress disorder (PTSD) and associated sleep disturbances and nightmares. The alpha-1 antagonist prazosin reduces sleep disturbances a...

    Brooks R. Keeshin, Qian Ding, Angela P. Presson in Neurology and Therapy (2017)

  10. Article

    Retraction Note to: Randomized clinical trial of arginine-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing gastric cancer surgery

    Hongyan Zhao, Hongying Zhao, Yu Wang in Journal of Cancer Research and Clinical On… (2015)

  11. Article

    Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats

    To investigate the protective effects of hydrogen sulfide (H2S) against inflammation, oxidative stress and apoptosis in a rat model of resuscitated hemorrhagic shock.

    Dun-quan Xu, Cao Gao, Wen Niu, Yan Li, Yan-xia Wang in Acta Pharmacologica Sinica (2013)

  12. No Access

    Article

    RETRACTED ARTICLE: Randomized clinical trial of arginine-supplemented enteral nutrition versus standard enteral nutrition in patients undergoing gastric cancer surgery

    Significant malnutrition exists in a high percentage of patients with gastric cancer. It is, therefore, crucial to establish an effective means to provide nutrition for these patients. This prospective, random...

    Hongyan Zhao, Hongying Zhao, Yu Wang in Journal of Cancer Research and Clinical On… (2013)

  13. No Access

    Article

    Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion

    Hepatoma-derived growth factor (HDGF), a heparin-binding growth factor, has a wide range of biological functions, including mitogenic activity and vascular development. Recent studies demonstrated that HDGF al...

    Maolan Li, Jun Shen, **angsong Wu, Bingtai Zhang, Rui Zhang, Hao Weng in Medical Oncology (2013)

  14. No Access

    Article

    Predictive factors of brain metastasis in patients with breast cancer

    The aim of this study is to determine the risk factors associated with metastasis to the brain of primary breast cancer patients and evaluate a predictive model. The clinicopathological characteristics of 206 ...

    Jun Xue, Gang Peng, **g-Song Yang, Qian Ding, **g Cheng in Medical Oncology (2013)

  15. No Access

    Article

    PI-103 sensitizes acute myeloid leukemia stem cells to daunorubicin-induced cytotoxicity

    To date, acute myeloid leukemia (AML) shows very poor outcome for conventional chemotherapy. Leukemia stem cells (LSCs) are insensitive to conventional chemotherapeutic drugs and play a central role in the pat...

    Qian Ding, Ran Gu, Jiayi Liang, **angzhong Zhang, Yunxian Chen in Medical Oncology (2013)

  16. Article

    Cysteinyl leukotriene receptor 1 partially mediates brain cryoinjury in mice

    To determine whether the cysteinyl leukotriene receptor 1 (CysLT1 receptor) modulates brain cryoinjury and whether the CysLT1 receptor antagonist pranlukast exerts a time-dependent protective effect on cryoinjury...

    Qian Ding, San-hua Fang, Yu Zhou, Li-hui Zhang in Acta Pharmacologica Sinica (2007)

  17. Article

    Cysteinyl leukotriene receptor 1 is involved in N-methyl-D-aspartate-mediated neuronal injury in mice

    To determine whether cysteinyl leukotriene receptor 1 (CysLT1 receptor) is involved in N-methyl-D-aspartate (NMDA)-induced excitotoxic injury in the mouse brain.

    Qian Ding, Er-qing Wei, Yan-jun Zhang, Wei-** Zhang in Acta Pharmacologica Sinica (2006)