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Article
Multi-scale Analysis of Supply–Demand Relationship of Ecosystem Services and Zoning Management in a Key Ecological-Restoration City (Ganzhou) of China
With the rapid development of economy and society, decision-makers need a deep understanding of the role of sustainable ecosystem management in practical application, which is crucial to the sustainable develo...
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Article
Open AccessRelationship of urinary glyphosate concentrations with glycosylated hemoglobin and diabetes in US adults: a cross-sectional study
Glyphosate is a commonly used herbicide worldwide and is purportedly associated with multiple health effects. Research assessing the association of glyphosate concentrations with glycosylated hemoglobin (HbA1c...
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Article
Hawthorn Fruit (Crataegus spp.) Polysaccharides Exhibit Immunomodulatory Activity on Macrophages via TLR4/NF-κB Signaling Activation
The immunostimulatory effects and the involved molecular mechanisms of polysaccharides from hawthorn fruit (Crataegus spp.) have not been well understood. In this study, the chemical composition, monosaccharide c...
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Article
Association Between Prenatal Per- and Polyfluoroalkyl Substance Exposure and Maternal Serum Total Bile Acid Levels During Pregnancy: Effect Modification by Infant Sex and Maternal Prepregnancy BMI
Bile acids play an important role in metabolic modulation and elevated serum total bile acid (sTBA) levels during pregnancy are linked to adverse perinatal outcomes. Previous studies have reported that per- an...
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Article
Open AccessPlasma ctDNA enhances the tissue-based detection of oncodriver mutations in colorectal cancer
The advent of circulating tumor DNA (ctDNA) technology has provided a convenient and noninvasive means to continuously monitor cancer genomic data, facilitating personalized cancer treatment. This study aimed ...
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Article
Role of m6A modifications in immune evasion and immunotherapy
RNA modification has garnered increasing attention in recent years due to its pivotal role in tumorigenesis and immune surveillance. N6-methyladenosine (m6A) modification is the most prevalent RNA modification, w...
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Article
Role of adhesion molecules in cancer and targeted therapy
Adhesion molecules mediate cell-to-cell and cell-to-extracellular matrix interactions and transmit mechanical and chemical signals among them. Various mechanisms deregulate adhesion molecules in cancer, enabli...
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Article
Open AccessAssociation between TB delay and TB treatment outcomes in HIV-TB co-infected patients: a study based on the multilevel propensity score method
HIV-tuberculosis (HIV-TB) co-infection is a significant public health concern worldwide. TB delay, consisting of patient delay, diagnostic delay, treatment delay, increases the risk of adverse anti-TB treatmen...
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Article
Open AccessOxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3
Oxygen is essential for aerobic organisms, but little is known about its role in antiviral immunity. Here, we report that during responses to viral infection, hypoxic conditions repress antiviral-responsive ge...
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Article
Open AccessCircCDYL2 bolsters radiotherapy resistance in nasopharyngeal carcinoma by promoting RAD51 translation initiation for enhanced homologous recombination repair
Radiation therapy stands to be one of the primary approaches in the clinical treatment of malignant tumors. Nasopharyngeal Carcinoma, a malignancy predominantly treated with radiation therapy, provides an inva...
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Article
Open AccessMaternal vitamin D status and risk of gestational diabetes mellitus in twin pregnancies: a longitudinal twin pregnancies birth cohort study
Gestational diabetes mellitus (GDM) is a common complication of pregnancy, with significant short-term and long-term implications for both mothers and their offspring. Previous studies have indicated the poten...
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Article
Open AccessStudy of the mandibular canal and its surrounding canals by multi-view cone-beam computed tomography
To determine the mandibular anatomical structures by observing cone-beam computed tomography (CBCT) from multiple angles.
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Article
Cost-Effectiveness and Clinical Outcomes of Secondary Hyperparathyroidism Treatments in Patients with Chronic Kidney Disease
The study addresses the challenge of treating secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) patients, focusing on the cost-effectiveness of surgical versus pharmacological interventions....
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Article
The costs and opportunities of overload: exploring the double-edged sword effect of unreasonable tasks on thriving at work
Over the past decade, the academic community has been increasingly interested in the impact of “unreasonable tasks,” a work-related stressor. Extensive research has consistently demonstrated the detrimental ef...
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Article
Evolutionary patterns and influencing factors of relationships among ecosystem services in the hilly red soil region of Southern China
As a crucial ecological protection area in China, the Southern hilly red soil region is characterized by uneven spatial and temporal distribution of ecological landscape elements, unpredictable and changeable ...
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Article
Open AccessAssociation between prenatal exposure to alkylphenols and intelligence quotient among preschool children: sex-specific effects
While prenatal exposure to alkylphenols (APs) has been demonstrated to be associated with neurodevelopmental impairments in animals, the evidence from epidemiological studies remains limited and inconclusive. ...
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Article
Open AccessThe roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming
One of the key features of cancer is energy metabolic reprogramming which is tightly related to cancer proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class of RNAs having no pro...
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Article
Open AccessInteracting and joint effects of triglyceride-glucose index (TyG) and body mass index on stroke risk and the mediating role of TyG in middle-aged and older Chinese adults: a nationwide prospective cohort study
Individuals who are overweight or obese often develop insulin resistance, mediation of the association between body mass index (BMI) and stroke risk through the triglyceride-glucose index (TyG) seems plausible...
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Article
Efficacy and Safety of Different Doses of Rivaroxaban and Risk Factors for Bleeding in Elderly Patients with Venous Thromboembolism: A Real-World, Multicenter, Observational, Cohort Study
Venous thromboembolism (VTE) consists of deep vein thrombosis (DVT) and pulmonary embolism (PE). Rivaroxaban is a direct oral anticoagulant (DOAC) inhibiting activated coagulation factor X (FXa), and exerts se...
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Article
HPV E6/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor
Human papillomavirus (HPV) is a class of envelope-free double-stranded DNA virus. HPV infection has been strongly associated with the development of many malignancies, such as cervical, anal and oral cancers. ...
