13 Result(s)
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Open AccessMap** and functional characterization of structural variation in 1060 pig genomes
Structural variations (SVs) have significant impacts on complex phenotypes by rearranging large amounts of DNA sequence.
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Open AccessPig pangenome graph reveals functional features of non-reference sequences
The reliance on a solitary linear reference genome has imposed a significant constraint on our comprehensive understanding of genetic variation in animals. This constraint is particularly pronounced for non-re...
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Open AccessA compendium of genetic regulatory effects across pig tissues
The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms...
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Open AccessA web tool for the global identification of pig breeds
Natural and artificial selection for more than 9000 years have led to a variety of domestic pig breeds. Accurate identification of pig breeds is important for breed conservation, sustainable breeding, pork tra...
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Open AccessGenome-wide selection signatures detection in Shanghai Holstein cattle population identified genes related to adaption, health and reproduction traits
Over several decades, a wide range of natural and artificial selection events in response to subtropical environments, intensive pasture and intensive feedlot systems have greatly changed the customary behavio...
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Association study between gene polymorphisms in PPAR signaling pathway and porcine meat quality traits
There is increasing evidence suggesting that fatty acids biosynthesis and metabolism are regulated by peroxisome proliferator-activated receptors (PPARs), mostly through the PPAR signaling pathway at the trans...
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Open AccessThe prediction of the porcine pre-microRNAs in genome-wide based on support vector machine (SVM) and homology searching
MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression by targeting mRNAs for translation repression or mRNA degradation. Although many miRNAs have been discovered and studied in...
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WRKY gene family evolution in Arabidopsis thaliana
The Arabidopsis thaliana WRKY proteins are characterized by a sequence of 60 amino acids including WRKY domain. It is well established that these proteins are involved in the regulation of various physiological p...
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Uncovering the transcriptional circuitry in skeletal muscle regeneration
Skeletal muscle has a remarkable ability to regenerate after repeated and complete destruction of the tissue. The healing phases for an injured muscle undergo an activation program controlled by a dynamically ...
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Article
Molecular selection and functional divergence of HIF-α proteins in vertebrates
HIF-α transcription factors, as key master regulators of oxygen homeostasis, constitute a subgroup of the large bHLH-PAS transcription factor family and have been identified in many vertebrates. Although the a...
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Comparative analysis of vertebrate PEPT1 and PEPT2 genes
The plasma membrane transport proteins belong to SoLute Carrier 15 (SLC15) family and two members of this family have been characterized extensively in higher vertebrates, namely PEPT1 and PEPT2. Despite many ...
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Comparative analysis of MTF-1 binding sites between human and mouse
MTF-1 is a crucial transcription factor involved in the cellular response to heavy-metal load and other stresses by specifically binding to metal response elements (MREs). Thus far only a handful of direct tar...
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Open AccessRegression-based approach for testing the association between multi-region haplotype configuration and complex trait
It is quite common that the genetic architecture of complex traits involves many genes and their interactions. Therefore, dealing with multiple unlinked genomic regions simultaneously is desirable.
