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    Article

    SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice

    Administration of CHK1-targeted anticancer therapies is associated with an increased cumulative risk of cardiac complications, which is further amplified when combined with gemcitabine. However, the underlying...

    Jia-Wen Chen, Tian-Kai Shan, Tian-Wen Wei, Qi-Qi Jiang, Chong Du… in Archives of Toxicology (2023)