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  1. Article

    Open Access

    Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination

    It has been well known that androgen receptor (AR) is critical to prostate cancer development and progression. It has also been documented that AR is expressed in more than 60% of breast tumors, which promotes...

    Yuning Liao, **aohong **a, Ningning Liu, Jianyu Cai, Zhiqiang Guo, Yanling Li… in Oncogene (2018)

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    Article

    A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

    Based on the central role of the ubiquitin–proteasome system (UPS) in the degradation of cellular proteins, proteasome inhibition has been considered an attractive approach for anticancer therapy. Deubiquitina...

    C Zhao, X Chen, D Zang, X Lan, S Liao, C Yang, P Zhang, J Wu, X Li, N Liu… in Oncogene (2016)

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    Article

    Proteasome inhibitors induce AMPK activation via CaMKKβ in human breast cancer cells

    The purpose of present study is to examine the mechanism of the 5′-AMP-activated protein kinase (AMPK) activation induced by proteasome inhibitors. AMPK activation and ubiquitin proteasome system (UPS) inhibit...

    Rahul R. Deshmukh, Q. ** Dou in Breast Cancer Research and Treatment (2015)

  4. No Access

    Article

    Transcriptional activation of breast cancer-associated gene 2 by estrogen receptor

    RNF115, or Breast Cancer-Associated Gene 2 (BCA2), encodes a RING-finger ubiquitin E3 ligase, expression of which was associated with estrogen receptor (ER)-positive status in human breast tumors. Although the...

    Fathima R. Kona, Karri Stark, Luke Bisoski… in Breast Cancer Research and Treatment (2012)

  5. No Access

    Article

    Targeted proteasome inhibition by Velcade induces apoptosis in human mesothelioma and breast cancer cell lines

    Thoracic malignancies and human breast cancer (HBC) continue to be aggressive solid tumors that are poor responders to the existing conventional standard chemotherapeutic approaches. Malignant pleural mesothel...

    Ying Wang, Arun K. Rishi… in Cancer Chemotherapy and Pharmacology (2010)