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    Optimization of intracerebroventricular streptozotocin dose for the induction of neuroinflammation and memory impairments in rats

    Intracerebroventricular (ICV) injection of streptozotocin (STZ) is a well established procedure to induce neuroinflammation leading to dementia in experimental animals. However, the optimal dose of STZ has not...

    Rupsa Ghosh, Susmita Sil, Pritha Gupta, Tusharkanti Ghosh in Metabolic Brain Disease (2020)

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    Intracerebroventricular Aβ-Induced Neuroinflammation Alters Peripheral Immune Responses in Rats

    An important marker in Alzheimer disease (AD) is the abnormal production and accumulation of β-amyloid peptide (Aß) in brain. It produces oxidative damage in neurons and inflammation due to its neurotoxic prop...

    Pritha Gupta, Susmita Sil, Rupsa Ghosh, Arijit Ghosh in Journal of Molecular Neuroscience (2018)

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    Protective effects of black tea-TV 25 on the cognitive impairments and some peripheral immune responses in intracerebroventricular colchicine injected rats

    India is the largest consumer of black tea in the world, which has been reported to have different protective functions in several diseases. TV 25 variety back tea has high content of polyphenols and has anti-...

    Susmita Sil, Kaushik Bhandari, Pritha Gupta in Oriental Pharmacy and Experimental Medicine (2018)

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    Dual Role of Vitamin C on the Neuroinflammation Mediated Neurodegeneration and Memory Impairments in Colchicine Induced Rat Model of Alzheimer Disease

    The neurodegeneration in colchicine induced AD rats (cAD) is mediated by cox-2 linked neuroinflammation. The importance of ROS in the inflammatory process in cAD has not been identified, which may be deciphere...

    Susmita Sil, Tusharkanti Ghosh, Pritha Gupta in Journal of Molecular Neuroscience (2016)