8 Result(s)
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Pradeep K Singh
Science, Humanities and Social Sciences, multidisciplinary
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessCell free DNA from respiratory pathogens is detectable in the blood plasma of Cystic Fibrosis patients
Diagnostically informative microbial cell-free DNA (cfDNA) can be detected from blood plasma during fulminant infections such as sepsis. However, the potential for DNA from airway pathogens to enter the circul...
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Article
Open AccessGenetic interaction involving photoperiod-responsive Hd1 promotes early flowering under long-day conditions in rice
Although flowering in rice has been extensively investigated, few studies focused on genetic interactions. Flowering evaluation of two recombinant inbred line (RIL) populations involving photo-insensitive rice...
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Article
Open AccessStructure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes
Proteasome inhibitors benefit patients with multiple myeloma and B cell-dependent autoimmune disorders but exert toxicity from inhibition of proteasomes in other cells. Toxicity should be minimized by reversib...
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Open AccessIn vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075
The nosocomial pathogen Acinetobacter baumannii is a frequent cause of hospital-acquired infections worldwide and is a challenge for treatment due to its evolved resistance to antibiotics, including carbapenems. ...
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Article
Open AccessEffect of curcumin analogs onα-synuclein aggregation and cytotoxicity
Alpha-synuclein (α-Syn) aggregation into oligomers and fibrils is associated with dopaminergic neuron loss occurring in Parkinson’s disease (PD) pathogenesis. Compounds that modulate α-Syn aggregation and inte...
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Open AccessStructure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation
Mechanistic understanding of nucleation dependent polymerization by α-synuclein (α-Syn) into toxic oligomers and amyloids is important for the drug development against Parkinson's disease. However the structur...
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A component of innate immunity prevents bacterial biofilm development
Antimicrobial factors form one arm of the innate immune system, which protects mucosal surfaces from bacterial infection1,2,3. These factors can rapidly kill bacteria deposited on mucosal surfaces and prevent acu...
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Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
The bacterium Pseudomonas aeruginosa permanently colonizes cystic fibrosis lungs despite aggressive antibiotic treatment1,2,3. This suggests that P. aeruginosa might exist as biofilms—structured communities of ba...
