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Article
Open AccessHigh-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos
Three-dimensional (3D) organoid cultures are flexible systems to interrogate cellular growth, morphology, multicellular spatial architecture, and cellular interactions in response to treatment. However, comput...
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Article
Open AccessHigh-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts
The processes by which tumors evolve are essential to the efficacy of treatment, but quantitative understanding of intratumoral dynamics has been limited. Although intratumoral heterogeneity is common, quantif...