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  1. Article

    Open Access

    High-throughput deconvolution of 3D organoid dynamics at cellular resolution for cancer pharmacology with Cellos

    Three-dimensional (3D) organoid cultures are flexible systems to interrogate cellular growth, morphology, multicellular spatial architecture, and cellular interactions in response to treatment. However, comput...

    Patience Mukashyaka, Pooja Kumar, David J. Mellert in Nature Communications (2023)

  2. Article

    Open Access

    High-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts

    The processes by which tumors evolve are essential to the efficacy of treatment, but quantitative understanding of intratumoral dynamics has been limited. Although intratumoral heterogeneity is common, quantif...

    Hyunsoo Kim, Pooja Kumar, Francesca Menghi, Javad Noorbakhsh in Scientific Reports (2018)