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Article
Application of Repetitive Sequences in Fish Cell Depletion as a Target for the CRISPR/Cas9 System
Specific cell depletion is a common means to study the physiological function of cell lineages and tissue regeneration. However, 100% depletion is difficult to achieve with existing cell depletion strategies. ...
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Article
Cu/photoredox-catalyzed decarboxylative radical C(sp3)-C(sp3) cross-coupling reactions
A radical decarboxylative C(sp3)-C(sp3) cross-coupling of NHPI esters and cyclopropanols was developed by combining photocatalysis and copper catalysis, which presents the efficient access to β-benzyl ketones in ...
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Article
Spatiotemporal characteristics of clear-air turbulence (CAT) potential in China during 1979–2020
Air turbulence, especially the clear-air turbulence (CAT), always affects flight safety. Based on six CAT diagnostics and ERA5 reanalysis data, the spatiotemporal characteristics of CAT potential in the middle...
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Article
Regio- and enantioselective remote dioxygenation of internal alkenes
Methods for the enantioselective direct oxygenation of internal alkenes have provided chemists with versatile and powerful toolboxes for the synthesis of optically pure alcohols, one of the most privileged str...
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Article
Open AccessSMPD1 expression profile and mutation landscape help decipher genotype–phenotype association and precision diagnosis for acid sphingomyelinase deficiency
Acid sphingomyelinase deficiency (ASMD) disorder, also known as Niemann–Pick disease (NPD) is a rare genetic disease caused by mutations in SMPD1 gene, which encodes sphingomyelin phosphodiesterase (ASM). Except ...
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Chapter and Conference Paper
A RF Fingerprint Clustering Method Based on Automatic Feature Extractor
RF fingerprint technology has received extensive attention and research in recent years due to its immutable nature. RF fingerprinting technology can be used as a wireless network security mechanism alone or c...
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Article
Future projection of extreme precipitation within CORDEX East Asia phase II: multi-model ensemble
Driven by the outputs of four global climate models from Coupled Model Intercomparison Project Phase 5, a long-term downscaling and projection under the RCP8.5 scenario is conducted within the Coordinated Regi...
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Article
Catalytic remote hydrohalogenation of internal alkenes
Primary alkyl halides have broad utility as fine chemicals in organic synthesis. The direct halogenation of alkenes is one of the most efficient approaches for the synthesis of these halides. Internal alkenes,...
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Article
Convection-permitting regional climate simulations over Tibetan Plateau: re-initialization versus spectral nudging
Two regional climate simulation experiments (spectral nudging and re-initialization) at convection-permitting scale are conducted using the WRF model driven by the 4th generation Global Reanalysis data (ERA5) ...
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Article
Copper-catalysed asymmetric radical cyanation
Catalytic asymmetric cyanation is a straightforward route to α-chiral nitriles that has previously relied on the enantioselective attack of cyanide on unsaturated electrophiles or the hydrocyanation of alkenes...
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Article
Open AccessClinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19
Synthetic glucocorticoid dexamethasone is the first trial-proven drug that reduces COVID-19 mortality by suppressing immune system. In contrast, interferons are a crucial component of host antiviral immunity a...
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Article
Palladium-catalysed enantioselective diacetoxylation of terminal alkenes
Optically pure 1,2-diols are one of the most privileged structural motifs. They are not only frequently found in natural products and drugs, but are also regarded as very useful synthons in organic synthesis. ...
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Reference Work Entry In depth
N,N′-Difluoro-1,4-Diazoniabicyclo[2.2.2]octane Salt Electrophilic Fluorination
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Article
Iodine(III) reagent (ABX—N3)-induced intermolecular anti-Markovnikov hydroazidation of unactivated alkenes
Anti-Markovnikov hydroazidation of unactivated alkenes using ABX2014;N3 as an initiator has been developed at room temperature, wherein hydrogen azide (HN3) acts as both hydrogen and azidating agent. Notably, the...
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Article
Site-specific allylic C–H bond functionalization with a copper-bound N-centred radical
Methods for selective C–H bond functionalization have provided chemists with versatile and powerful toolboxes for synthesis, such as the late-stage modification of a lead compound without the need for lengthy ...
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Article
Future projection of heat waves over China under global warming within the CORDEX-EA-II project
Driven by four global climate models (GCMs) from the Coupled Model Intercomparison Project Phase 5 (CMIP5) (i.e., CNRM-CM5, EC-EARTH, GFDL-ESM2M and MPI-ESM-LR) under the Representative Concentration Pathway 8...
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Article
Open AccessMultimodal imaging of the retina and choroid in healthy Macaca fascicularis at different ages
The aim of this study was to identify the morphological features of the retina and choroid in Macaca fascicularis of different ages using multimodal imaging.
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Article
Open AccessAssociation between Thalamocortical Functional Connectivity Abnormalities and Cognitive Deficits in Schizophrenia
Cognitive deficits are considered a core component of schizophrenia and may predict functional outcome. However, the neural underpinnings of neuropsychological impairment remain to be fully elucidated. Data of...
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Article
Optimization of the Gal4/UAS transgenic tools in zebrafish
The Gal4/UAS system provides a powerful tool to analyze the function of genes. The system has been employed extensively in zebrafish; however, cytotoxicity of Gal4 and methylation of UAS can hinder future appl...
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Living Reference Work Entry In depth
N,N′-Difluoro-1,4-Diazoniabicyclo[2.2.2]octane Salt Electrophilic Fluorination