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  1. No Access

    Article

    Application of Repetitive Sequences in Fish Cell Depletion as a Target for the CRISPR/Cas9 System

    Specific cell depletion is a common means to study the physiological function of cell lineages and tissue regeneration. However, 100% depletion is difficult to achieve with existing cell depletion strategies. ...

    Yunsheng Zhang, Hu **a, Wei Peng, Lanhai Liu, Liangguo Liu in Marine Biotechnology (2024)

  2. No Access

    Article

    Cu/photoredox-catalyzed decarboxylative radical C(sp3)-C(sp3) cross-coupling reactions

    A radical decarboxylative C(sp3)-C(sp3) cross-coupling of NHPI esters and cyclopropanols was developed by combining photocatalysis and copper catalysis, which presents the efficient access to β-benzyl ketones in ...

    Chao Jiang, Pinhong Chen, Guosheng Liu in Science China Chemistry (2023)

  3. No Access

    Article

    Spatiotemporal characteristics of clear-air turbulence (CAT) potential in China during 1979–2020

    Air turbulence, especially the clear-air turbulence (CAT), always affects flight safety. Based on six CAT diagnostics and ERA5 reanalysis data, the spatiotemporal characteristics of CAT potential in the middle...

    Boyan Hu, Pinhong Hui, **feng Ding, Xuguang Sun, Jian** Tang in Climate Dynamics (2023)

  4. No Access

    Article

    Regio- and enantioselective remote dioxygenation of internal alkenes

    Methods for the enantioselective direct oxygenation of internal alkenes have provided chemists with versatile and powerful toolboxes for the synthesis of optically pure alcohols, one of the most privileged str...

    **aonan Li, Tilong Yang, Jiayuan Li, **ang Li, Pinhong Chen in Nature Chemistry (2023)

  5. Article

    Open Access

    SMPD1 expression profile and mutation landscape help decipher genotype–phenotype association and precision diagnosis for acid sphingomyelinase deficiency

    Acid sphingomyelinase deficiency (ASMD) disorder, also known as Niemann–Pick disease (NPD) is a rare genetic disease caused by mutations in SMPD1 gene, which encodes sphingomyelin phosphodiesterase (ASM). Except ...

    Ruisong Wang, Ziyi Qin, Long Huang, Huiling Luo, Han Peng, **nyu Zhou in Hereditas (2023)

  6. No Access

    Chapter and Conference Paper

    A RF Fingerprint Clustering Method Based on Automatic Feature Extractor

    RF fingerprint technology has received extensive attention and research in recent years due to its immutable nature. RF fingerprinting technology can be used as a wireless network security mechanism alone or c...

    Pinhong **ao, Di Lin, Mengjuan Wang in Machine Learning and Intelligent Communication (2023)

  7. No Access

    Article

    Future projection of extreme precipitation within CORDEX East Asia phase II: multi-model ensemble

    Driven by the outputs of four global climate models from Coupled Model Intercomparison Project Phase 5, a long-term downscaling and projection under the RCP8.5 scenario is conducted within the Coordinated Regi...

    Pinhong Hui, Fenfen Wei, Yuxin **ao, Jie Yang in Theoretical and Applied Climatology (2022)

  8. No Access

    Article

    Catalytic remote hydrohalogenation of internal alkenes

    Primary alkyl halides have broad utility as fine chemicals in organic synthesis. The direct halogenation of alkenes is one of the most efficient approaches for the synthesis of these halides. Internal alkenes,...

    **ang Li, Jianbo **, Pinhong Chen, Guosheng Liu in Nature Chemistry (2022)

  9. No Access

    Article

    Convection-permitting regional climate simulations over Tibetan Plateau: re-initialization versus spectral nudging

    Two regional climate simulation experiments (spectral nudging and re-initialization) at convection-permitting scale are conducted using the WRF model driven by the 4th generation Global Reanalysis data (ERA5) ...

    Mengnan Ma, Pinhong Hui, Dongqing Liu, Peifeng Zhou, Jian** Tang in Climate Dynamics (2022)

  10. No Access

    Article

    Copper-catalysed asymmetric radical cyanation

    Catalytic asymmetric cyanation is a straightforward route to α-chiral nitriles that has previously relied on the enantioselective attack of cyanide on unsaturated electrophiles or the hydrocyanation of alkenes...

    Fei Wang, Pinhong Chen, Guosheng Liu in Nature Synthesis (2022)

  11. Article

    Open Access

    Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19

    Synthetic glucocorticoid dexamethasone is the first trial-proven drug that reduces COVID-19 mortality by suppressing immune system. In contrast, interferons are a crucial component of host antiviral immunity a...

    Yingying Lu, Feng Liu, Gangling Tong, Feng Qiu in Signal Transduction and Targeted Therapy (2021)

  12. No Access

    Article

    Palladium-catalysed enantioselective diacetoxylation of terminal alkenes

    Optically pure 1,2-diols are one of the most privileged structural motifs. They are not only frequently found in natural products and drugs, but are also regarded as very useful synthons in organic synthesis. ...

    Bing Tian, Pinhong Chen, Xuebing Leng, Guosheng Liu in Nature Catalysis (2021)

  13. No Access

    Reference Work Entry In depth

    N,N′-Difluoro-1,4-Diazoniabicyclo[2.2.2]octane Salt Electrophilic Fluorination

    Chaohuang Chen, Pinhong Chen, Guosheng Liu in Fluorination (2020)

  14. No Access

    Article

    Iodine(III) reagent (ABX—N3)-induced intermolecular anti-Markovnikov hydroazidation of unactivated alkenes

    Anti-Markovnikov hydroazidation of unactivated alkenes using ABX2014;N3 as an initiator has been developed at room temperature, wherein hydrogen azide (HN3) acts as both hydrogen and azidating agent. Notably, the...

    **aonan Li, Pinhong Chen, Guosheng Liu in Science China Chemistry (2019)

  15. No Access

    Article

    Site-specific allylic C–H bond functionalization with a copper-bound N-centred radical

    Methods for selective C–H bond functionalization have provided chemists with versatile and powerful toolboxes for synthesis, such as the late-stage modification of a lead compound without the need for lengthy ...

    Jiayuan Li, Zhihan Zhang, Lianqian Wu, Wen Zhang, Pinhong Chen, Zhenyang Lin in Nature (2019)

  16. No Access

    Article

    Future projection of heat waves over China under global warming within the CORDEX-EA-II project

    Driven by four global climate models (GCMs) from the Coupled Model Intercomparison Project Phase 5 (CMIP5) (i.e., CNRM-CM5, EC-EARTH, GFDL-ESM2M and MPI-ESM-LR) under the Representative Concentration Pathway 8...

    Pinya Wang, Pinhong Hui, Daokai Xue, Jian** Tang in Climate Dynamics (2019)

  17. Article

    Open Access

    Multimodal imaging of the retina and choroid in healthy Macaca fascicularis at different ages

    The aim of this study was to identify the morphological features of the retina and choroid in Macaca fascicularis of different ages using multimodal imaging.

    Shuxin Fan, **aoyan Ding, Pinhong Rao in Graefe's Archive for Clinical and Experime… (2019)

  18. Article

    Open Access

    Association between Thalamocortical Functional Connectivity Abnormalities and Cognitive Deficits in Schizophrenia

    Cognitive deficits are considered a core component of schizophrenia and may predict functional outcome. However, the neural underpinnings of neuropsychological impairment remain to be fully elucidated. Data of...

    Pinhong Chen, Enmao Ye, **ao **, Yuyang Zhu, Lubin Wang in Scientific Reports (2019)

  19. No Access

    Article

    Optimization of the Gal4/UAS transgenic tools in zebrafish

    The Gal4/UAS system provides a powerful tool to analyze the function of genes. The system has been employed extensively in zebrafish; however, cytotoxicity of Gal4 and methylation of UAS can hinder future appl...

    Yunsheng Zhang, Jiawei Ouyang, **grong Qie in Applied Microbiology and Biotechnology (2019)

  20. No Access

    Living Reference Work Entry In depth

    N,N′-Difluoro-1,4-Diazoniabicyclo[2.2.2]octane Salt Electrophilic Fluorination

    Chaohuang Chen, Pinhong Chen, Guosheng Liu in Fluorination

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