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Article
Validation of single nucleotide polymorphism quantification in pooled DNA samples with SNaPIT™
Association studies using genome scans to identify quantitative trait loci for multifactorial disorders, with anything approaching reasonable power, have been compromised by the need for a very dense array of ...
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Article
Open AccessTransient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1)
The 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of the dopamine transporter gene (DAT1) has been associated with a range of psychiatric phenotypes, most n...
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Article
Continuity and Change in Preschool ADHD Symptoms: Longitudinal Genetic Analysis with Contrast Effects
The genetic and environmental mediation of continuity and change in parent-reported ADHD symptoms were investigated in a cohort of over 6000 twin pairs at 2, 3 and 4 years of age. Genetic analyses of the cross...
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Article
Open AccessNo evidence for the association of DRD4 with ADHD in a Taiwanese population within-family study
Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent and highly heritable childhood disorder. The dopamine D4 receptor (DRD4) gene has shown a genetic association with ADHD in Caucasian populations w...
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Article
Open AccessSequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains
The Spontaneously Hypertensive Rat (SHR) shows a number of behaviours that closely parallel those seen in children with attention-deficit hyperactivity disorder. These include motor hyperactivity, excessive re...
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Article
Open AccessThe IMAGE project: methodological issues for the molecular genetic analysis of ADHD
The genetic mechanisms involved in attention deficit hyperactivity disorder (ADHD) are being studied with considerable success by several centres worldwide. These studies confirm prior hypotheses about the rol...
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Article
Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder (ADHD) is a behavioral diagnosis based on the presence of developmentally inappropriate levels of impulsivity, overactivity, and inattentiveness. It is a familial condi...
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Article
Long-acting medications for the hyperkinetic disorders
A systematic review of published and unpublished data on the use of long-acting medications in ADHD and hyperkinetic disorder is reported, giving effect sizes and numbers-to-treat for extended-release stimulan...
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Article
Open AccessAssociation study between the monoamine oxidase A gene and attention deficit hyperactivity disorder in Taiwanese samples
Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable disorder of childhood characterized by inattention, hyperactivity and impulsivity. Molecular genetic and pharmacological studies...
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Article
Genetic Support for the Dual Nature of Attention Deficit Hyperactivity Disorder: Substantial Genetic Overlap Between the Inattentive and Hyperactive–impulsive Components
Attention deficit hyperactivity disorder (ADHD) is a common, complex and highly heritable disorder, characterised by inattentive, impulsive and overactive behaviour. Evidence for the heritability of ADHD measu...
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Article
High Heritability for a Composite Index of Children’s Activity Level Measures
Despite the high heritability of children’s activity level, which forms part of the core symptom domain of hyperactivity-impulsivity within attention deficit hyperactivity disorder (ADHD), there has only been ...
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Article
Actigraph data are reliable, with functional reliability increasing with aggregation
Motion sensor devices such as actigraphs are increasingly used in studies that seek to obtain an objective assessment of activity level. They have many advantages, and are useful additions to research in field...
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Article
Open AccessThe influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis
Low serotonergic (5-HT) activity correlates with increased impulsive-aggressive behavior, while the opposite association may apply to cognitive impulsiveness. Both types of impulsivity are associated with atte...
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Article
Open AccessAssociation study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder
Attention deficit hyperactivity disorder (ADHD) is a complex neurobehavioral disorder. The dopamine transporter gene (DAT1/SLC6A3) has been considered a good candidate for ADHD. Most association studies with ADHD...
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Article
Open AccessInvestigation of the serotonin 2C receptor gene in attention deficit hyperactivity disorder in UK samples
Attention deficit hyperactivity disorder (ADHD) is a common, childhood-onset neurodevelopmental disorder that is more frequent in males than females. Several genes on the X chromosome have been studied as cand...
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Article
Hyperactive-Impulsive Symptom Scores and Oppositional Behaviours Reflect Alternate Manifestations of a Single Liability
Attention deficit hyperactivity disorder and oppositional behaviours frequently co-occur, We aimed to study the etiology of this overlap in a general population–based twin sample, assessing the symptom domains...
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Article
Multicenter Analysis of the SLC6A3/DAT1 VNTR Haplotype in Persistent ADHD Suggests Differential Involvement of the Gene in Childhood and Persistent ADHD
Attention deficit/hyperactivity disorder (ADHD) is one of the most common neuropsychiatric disorders with a worldwide prevalence around 4–5% in children and 1–4% in adults. Although ADHD is highly heritable an...
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Article
Exploring the Relationship Between Autistic-Like Traits and ADHD Behaviors in Early Childhood: Findings from a Community Twin Study of 2-Year-Olds
Behaviors characteristic of autism and ADHD emerge in early childhood, yet research investigating their comorbidity has focused on older children. This study aimed to explore the nature of the relationship bet...
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Article
Open AccessAssociation study between a polymorphism at the 3'-untranslated region of CLOCK gene and attention deficit hyperactivity disorder
The circadian locomotor output cycles kaput (CLOCK) gene encodes protein regulation circadian rhythm and also plays some roles in neural transmitter systems including the dopamine system. Several lines of evidenc...
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Article
Open AccessEuropean consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD
Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several diff...
