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  1. No Access

    Article

    Nanomedicine targeting ferroptosis to overcome anticancer therapeutic resistance

    A potential reason for the failure of tumor therapies is treatment resistance. Resistance to chemotherapy, radiotherapy, and immunotherapy continues to be a major obstacle in clinic, resulting in tumor recurre...

    **g Cai, **aoding Xu, Phei Er Saw in Science China Life Sciences (2024)

  2. No Access

    Article

    Nanoparticle (NP)-mediated APOC1 silencing to inhibit MAPK/ERK and NF-κB pathway and suppress breast cancer growth and metastasis

    Breast cancer is one of the most common malignant tumors with high mortality and poor prognosis in women. There is an urgent need to discover new therapeutic targets for breast cancer metastasis. Herein, we id...

    Shaomin Liu, Fengqian Zhang, Yixia Liang, Guo Wu, Rong Liu… in Science China Life Sciences (2023)

  3. No Access

    Article

    Non-coding RNAs: the new central dogma of cancer biology

    The central dogma of molecular biology states that the functions of RNA revolve around protein translation. Until the last decade, most researches were geared towards characterization of RNAs as intermediaries...

    Phei Er Saw, **aoding Xu, Jianing Chen, Er-Wei Song in Science China Life Sciences (2021)

  4. Article

    Open Access

    Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis

    Spermidine has been known to inhibit the production of pro-inflammatory cytokines. However, there are no reports about anti-inflammatory effects of spermidine on osteoarthritis (OA). Herein, we examined whethe...

    Zhong Chen, Chuang-**n Lin, Bin Song, Chang-Chuan Li, Jun-**ong Qiu… in Cell Death & Disease (2020)

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  5. No Access

    Article

    siRNA therapeutics: a clinical reality

    Since the revolutionary discovery of RNA interference (RNAi), a remarkable progress has been achieved in understanding and harnessing gene silencing mechanism; especially in small interfering RNA (siRNA) thera...

    Phei Er Saw, Er-Wei Song in Science China Life Sciences (2020)

  6. No Access

    Article

    Chimeric antigen receptor T cells in solid tumors: a war against the tumor microenvironment

    Chimeric antigen receptor (CAR) T cell is a novel approach, which utilizes anti-tumor immunity for cancer treatment. As compared to the traditional cell-mediated immunity, CAR-T possesses the improved specific...

    Zijun Zhao, **aoyun **ao, Phei Er Saw, Wei Wu, Hongyan Huang… in Science China Life Sciences (2020)