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    Article

    Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

    Mark Daly, Ramnik Xavier and colleagues report that a 20-kb deletion polymorphism upstream of IRGM is associated with altered IRGM expression and Crohn's disease. They also show that manipulation of IRGM levels i...

    Steven A McCarroll, Alan Huett, Petric Kuballa, Shannon D Chilewski in Nature Genetics (2008)

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    Article

    Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

    We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in addition to the pre...

    John D Rioux, Ramnik J Xavier, Kent D Taylor, Mark S Silverberg in Nature Genetics (2007)