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Protocol
Use of CRISPR/Cas9 for the Modification of the Mouse Genome
The use of CRISPR/Cas9 to modify the mouse genome has gained immense interest in the past few years since it allows the direct modification of embryos, bypassing the need of labor-intensive procedures for the ...
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Chapter
Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics
Studies using human genetics have identified more than 160 loci that affect the risk of develo** inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Several of these...
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Article
Failure and exploitation of autophagy in human pathologies—cellular integrity between inflammation, infection, and cell survival
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Article
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
Mark Daly, Ramnik Xavier and colleagues report that a 20-kb deletion polymorphism upstream of IRGM is associated with altered IRGM expression and Crohn's disease. They also show that manipulation of IRGM levels i...
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Article
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in addition to the pre...
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Article
Open AccessThe human cadherin family protein hFat1 interacts with postsynaptic density PDZ domain-containing proteins