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6 Result(s)

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  1. No Access

    Protocol

    Use of CRISPR/Cas9 for the Modification of the Mouse Genome

    The use of CRISPR/Cas9 to modify the mouse genome has gained immense interest in the past few years since it allows the direct modification of embryos, bypassing the need of labor-intensive procedures for the ...

    Alexander Klimke, Steffen Güttler… in Target Identification and Validation in Dr… (2019)

  2. Chapter

    Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics

    Studies using human genetics have identified more than 160 loci that affect the risk of develo** inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Several of these...

    Natalia Nedelsky, Petric Kuballa… in Molecular Genetics of Inflammatory Bowel D… (2019)

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  3. No Access

    Article

    Failure and exploitation of autophagy in human pathologies—cellular integrity between inflammation, infection, and cell survival

    Petric Kuballa, Ramnik J. Xavier in Seminars in Immunopathology (2010)

  4. No Access

    Article

    Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

    Mark Daly, Ramnik Xavier and colleagues report that a 20-kb deletion polymorphism upstream of IRGM is associated with altered IRGM expression and Crohn's disease. They also show that manipulation of IRGM levels i...

    Steven A McCarroll, Alan Huett, Petric Kuballa, Shannon D Chilewski… in Nature Genetics (2008)

  5. No Access

    Article

    Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

    We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in addition to the pre...

    John D Rioux, Ramnik J Xavier, Kent D Taylor, Mark S Silverberg… in Nature Genetics (2007)

  6. Article

    Open Access

    The human cadherin family protein hFat1 interacts with postsynaptic density PDZ domain-containing proteins

    Dietmar Schreiner, Petric Kuballa, Hans Werner Hofer in BMC Neuroscience (2007)

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