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  1. No Access

    Article

    Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag

    Prime editors have a broad range of potential research and clinical applications. However, methods to delineate their genome-wide editing activities have generally relied on indirect genome-wide editing assess...

    Shun-Qing Liang, Pengpeng Liu, Karthikeyan Ponnienselvan, Sneha Suresh… in Nature Methods (2023)

  2. No Access

    Article

    LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria

    The accumulation of deleterious mitochondrial DNA (∆mtDNA) causes inherited mitochondrial diseases and ageing-associated decline in mitochondrial functions such as oxidative phosphorylation. Following mitochon...

    Qiyuan Yang, Pengpeng Liu, Nadine S. Anderson, Tomer Shpilka… in Nature Cell Biology (2022)

  3. No Access

    Article

    Long non-coding RNA A1BG-AS1 promotes tumorigenesis in breast cancer by sponging microRNA-485-5p and consequently increasing expression of FLOT1 expression

    The dysregulated long non-coding RNA A1BG antisense RNA 1 (A1BG-AS1) has been implicated in the oncogenicity of hepatocellular carcinoma. Using reverse transcription quantitative polymerase chain reaction in t...

    Shibin Cai, Yi Zhou, Ying Pan, Pengpeng Liu, Kaijie Yu, Shuzheng Chen in Human Cell (2021)

  4. No Access

    Article

    LINC00662 promotes hepatocellular carcinoma progression via altering genomic methylation profiles

    The identification of viability-associated long noncoding RNAs (lncRNAs) is a means of uncovering therapeutic approaches for hepatocellular carcinoma (HCC). In addition, aberrant genome-wide hypomethylation ha...

    Tao Guo, Cheng Gong, ** Wu, Shyue-Fang Battaglia-Hsu… in Cell Death & Differentiation (2020)

  5. Article

    Open Access

    NmeCas9 is an intrinsically high-fidelity genome-editing platform

    The development of CRISPR genome editing has transformed biomedical research. Most applications reported thus far rely upon the Cas9 protein from Streptococcus pyogenes SF370 (SpyCas9). With many RNA guides, wild...

    Nadia Amrani, **n D. Gao, Pengpeng Liu, Alireza Edraki, Aamir Mir… in Genome Biology (2018)

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  6. Article

    Regulation of transcriptionally active genes via the catalytically inactive Cas9 in C. elegans and D. rerio

    Lijiang Long, Hong Guo, Di Yao, Kai **ong, Yongjun Li, Pengpeng Liu… in Cell Research (2015)

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  7. Article

    Heritable/conditional genome editing in C. elegans using a CRISPR-Cas9 feeding system

    Pengpeng Liu, Lijiang Long, Kai **ong, Bo Yu, Nannan Chang, **g-Wei **ong… in Cell Research (2014)

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  8. Article

    mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C. elegans

    MicroRNA (miRNA) regulates gene expression in many cellular events, yet functions of only a few miRNAs are known in C. elegans. We analyzed the function of mir-35-41 unique to the worm, and show here that mir-35 ...

    Min Liu, Pengpeng Liu, Li Zhang, Qingchun Cai, Ge Gao, Wenxia Zhang… in Cell Research (2011)

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  9. No Access

    Article

    Effects of clinorotation on COL1A1-EGFP gene expression

    Bone-formation related gene plays a critical role in bone loss induced by space microgravity, however the exact mechanism is unclear. In this study, we aim to investigate the effect of microgravity on the acti...

    Zhongquan Dai, Yinghui Li, Bai Ding… in Science in China Series C: Life Sciences (2004)