![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
A Gγ subunit promoter T-DNA insertion mutant—A1-412 of Magnaporthe grisea is defective in appressorium formation, penetration and pathogenicity
In our previous studies, a nonpathogenic mutant of Magnaporthe grisea, A1-412, which was defective in appressorium formation, penetration and infectious growth, was obtained by T-DNA insertional mutagenesis. Here...
-
Article
Cloning, heterologous expression, and functional characterization of the nicotinate dehydrogenase gene from Pseudomonas putida KT2440
6-Hydroxynicotinate can be used for the production of drugs, pesticides and intermediate chemicals. Some Pseudomonas species were reported to be able to convert nicotinic acid to 6-hydroxynicotinate by nicotinate...
-
Article
Open AccessPreliminary molecular characterization of the human pathogen Angiostrongylus cantonensis
Human angiostrongyliasis is an emerging food-borne public health problem, with the number of cases increasing worldwide, especially in mainland China. Angiostrongylus cantonensis is the causative agent of this se...
-
Article
KCNQ1 loss-of-function mutation impairs gastric acid secretion in mice
The KCNQ1 channel is abundantly expressed in the gastric parietal cells. Although the functional coupling of KCNQ1 with the H+/K+-ATPase has already been confirmed on the basis of pharmacological kinetics, the ef...
-
Article
Cloning, expression and functional analysis of nicotinate dehydrogenase gene cluster from Comamonas testosteroni JA1 that can hydroxylate 3-cyanopyridine
A nicotinate dehydrogenase (NaDH) gene cluster was cloned from Comamonas testosteroni JA1. The enzyme, termed NaDHJA1, is composed of 21, 82, and 46 kDa subunits, respectivley containing [2Fe2S], Mo(V) and cytoch...
-
Article
Over-expression of microRNA169 confers enhanced drought tolerance to tomato
Plant miRNA regulates multiple developmental and physiological processes, including drought responses. We found that the accumulation of Sly-miR169 in tomato (Solanum lycopersicum) was induced by drought stress. ...
-
Article
Overexpression of SlGMEs leads to ascorbate accumulation with enhanced oxidative stress, cold, and salt tolerance in tomato
GDP-Mannose 3′,5′-epimerase (GME; EC 5.1.3.18) catalyses the conversion of GDP-d-mannose to GDP-l-galactose, an important step in the ascorbic acid (AsA) biosynthesis pathway in higher plants. In this study, two ...
-
Article
Expression of artificial microRNAs in tomato confers efficient and stable virus resistance in a cell-autonomous manner
Expression of artificial microRNAs (amiRNAs) in plants can target and degrade the invading viral RNA, consequently conferring virus resistance. Two amiRNAs, targeting the coding sequence shared by the 2a and 2...
-
Article
In vitro toxicity of nanosized copper particles in PC12 cells induced by oxidative stress
Recent evidence suggests that some nanomaterials, which are widely used in many fields, have health effects. In order to investigate the cytotoxicity induced by nanosized copper particles (nano-Cu), PC12 cells...
-
Article
Protective effects of leukemia inhibitory factor against oxidative stress during high glucose-induced apoptosis in podocytes
Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the interleukin-6 family of cytokines. In kidney, LIF regulates nephrogenesis, involves in tubular regeneration, responds to pro- and...
-
Article
Strong inbreeding depression and local outbreeding depression in the rewarding orchid Gymnadenia conopsea
Conservation of species threatened by habitat fragmentation is a major global challenge, and determining the genetic and demographic processes associated with isolation and reductions in population size will b...
-
Article
Developmental changes of BKCa channels depend on differentiation status in cultured podocytes
The podocyte is a remarkable cell type, which encases the capillaries of the kidney glomerulus. Podocytes are of keen interests because of their key roles in kidney development and disease. Large-conductance Ca2+
-
Article
Nanosized copper oxide induces apoptosis through oxidative stress in podocytes
Nanosized copper oxide (nano-CuO) has been widely used in many fields. Recent studies have shown that nano-CuO has toxic effects on various organs, but the effects of nano-CuO on kidney remain unclear. The aim...
-
Article
The role of glycogen synthase kinase-3β in glioma cell apoptosis induced by remifentanil
The aim of malignant glioma treatment is to inhibit tumor cell proliferation and induce tumor cell apoptosis. Remifentanil is a clinical anesthetic drug that can activate the N-methyl-D-aspartate (NMDA) recept...
-
Article
Increased response to oxidative stress challenge of nano-copper-induced apoptosis in mesangial cells
Recently, many studies reported that nanosized copper particles (nano-Cu, the particle size was around 15–30 nm), one of the nanometer materials, could induce nephrotoxicity. To detect the effect of nano-Cu on...
-
Article
Open AccessMKL1 inhibits cell cycle progression through p21 in podocytes
The glomerular podocyte is a highly specialized cell type with the ability to ultrafilter blood and support glomerular capillary pressure. However, little is known about the genetic programs leading to this fu...
-
Article
Thrombopoietin Signaling Pathway Regulates Hepatocyte Activation in Rat Liver Regeneration
Thrombopoietin (THPO) signaling pathway regulates cell activation and many other physiological activities. To study its role in liver regeneration (LR), hepatocytes were isolated from rat regenerating livers a...
-
Article
Epidemiological study and variation analysis of the porcine kobuvirus 3D gene in Sichuan province, China
-
Article
Aptamer-wrapped gold nanoparticles for the colorimetric detection of omethoate
Organophosphorous pesticide (OP) contamination could have serious adverse effects on human health and the environment. Due to the toxicity of OPs and the threat presented by their accidental or intentional rel...
-
Article
Open AccessA large family of Dscam genes with tandemly arrayed 5′ cassettes in Chelicerata
Drosophila Dscam1 (Down Syndrome Cell Adhesion Molecules) and vertebrate clustered protocadherins (Pcdhs) are two classic examples of the extraordinary isoform diversity from a single genomic locus. Dscam1 encode...