5 Result(s)
within
Pengfei Fang
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessSecond messenger Ap4A polymerizes target protein HINT1 to transduce signals in FcεRI-activated mast cells
Signal transduction systems enable organisms to monitor their external environments and accordingly adjust the cellular processes. In mast cells, the second messenger Ap4A binds to the histidine triad nucleotide-...
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Article
Open AccessBreast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
Metastasis is the main cause of death in cancer patients. TGF-β is pro-metastatic for malignant cancer cells. Here we report a loss-of-function screen in mice with metastasis as readout and identify OTUD1 as a...
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Article
Open AccessAminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor
Aminoacyl-tRNA synthetases (AARSs) catalyze an early step in protein synthesis, but also regulate diverse physiological processes in animal cells. These include angiogenesis and human threonyl-tRNA synthetase ...
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Article
Open AccessStructural basis for full-spectrum inhibition of translational functions on a tRNA synthetase
The polyketide natural product borrelidin displays antibacterial, antifungal, antimalarial, anticancer, insecticidal and herbicidal activities through the selective inhibition of threonyl-tRNA synthetase (ThrR...
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Article
Open AccessQuick and Facile Preparation of Visible light-Driven TiO2 Photocatalyst with High Absorption and Photocatalytic Activity
Self-do** TiO2 has recently attracted considerable attention for its high photocatalytic activity under visible-light irradiation. However, the literature reported synthetic methods until now were very time-con...
