10 Result(s)
within
Paul A. Janmey
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessThe Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation
Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell cycle arrest. This pathway has no...
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Article
Effects of extracellular matrix viscoelasticity on cellular behaviour
Substantial research over the past two decades has established that extracellular matrix (ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading, growth, proliferation, migr...
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Article
Emergence of tissue-like mechanics from fibrous networks confined by close-packed cells
The viscoelasticity of the crosslinked semiflexible polymer networks—such as the internal cytoskeleton and the extracellular matrix—that provide shape and mechanical resistance against deformation is assumed t...
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Article
Open AccessControl of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation
The mechanical properties of extracellular matrices can control the function of cells. Studies of cellular responses to biomimetic soft materials have been largely restricted to hydrogels and elastomers that h...
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Article
Open AccessUncoupling shear and uniaxial elastic moduli of semiflexible biopolymer networks: compression-softening and stretch-stiffening
Gels formed by semiflexible filaments such as most biopolymers exhibit non-linear behavior in their response to shear deformation, e.g., with a pronounced strain stiffening and negative normal stress. These ne...
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Article
Nonlinear elasticity in biological gels
Unlike most synthetic materials, biological materials often stiffen as they are strained. This property, critical for the physiological function of tissues such as blood vessels, lung parenchyma and blood clot...
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Article
Holding it together in the eye
To form tissues, like cells must clump together. The striking resemblance between one cell aggregate in flies and a cluster of soap bubbles points to a crucial role for surface mechanics in biological pattern ...
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Article
Effect of ATP on actin filament stiffness
ACTIN is an adenine nucleotide-binding protein and an ATPase1. The bound adenine nucleotide stabilizes the protein against denaturation2 and the ATPase activity, although not required for actin polymerization, af...
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Article
Resemblance of actin-binding protein/actin gels to covalently crosslinked networks
THE maintainance of the shape of cells is often due to their surface elasticity, which arises mainly from an actin-rich cytoplasmic cortex1,2. On locomotion, phagocytosis or fission, however, these cells become p...
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Article
Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate
The actin-binding protein gelsolin requires micromolar concentrations of calcium ions to sever actin filaments, to potentiate its binding to the end of the filament and to promote the polymerization of monomer...
