3 Result(s)
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Article
Open AccessNegative regulation of TGFβ-induced apoptosis by RAC1B enhances intestinal tumourigenesis
RAC1B is a tumour-related alternative splice isoform of the small GTPase RAC1, found overexpressed in a large number of tumour types. Building evidence suggests it promotes tumour progression but compelling in vi...
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Article
Open AccessTGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis
Recent studies have suggested increased plasticity of differentiated cells within the intestine to act both as intestinal stem cells (ISCs) and tumour-initiating cells. However, little is known of the processe...
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Protocol
Methods to Assess Myc Function in Intestinal Homeostasis, Regeneration, and Tumorigenesis
Within the intestinal epithelium, c-Myc has been characterized as a target of β-catenin-TCF signalling (He et al., Science 281:1509–1512, 1998). Given the most commonly mutated tumor suppressor gene within col...
