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  1. No Access

    Article

    Target-mediated exposure enhancement: a previously unexplored limit of TMDD

    Target-mediated drug disposition (TMDD) is often observed for targeted therapeutics, and manifests as decreases in clearance and volume of distribution with increasing dose as a result of saturable, high affin...

    Patrick M. Glassman, Vladimir R. Muzykantov in Journal of Pharmacokinetics and Pharmacody… (2020)

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    Article

    Physiologically-based pharmacokinetic modeling to predict the clinical pharmacokinetics of monoclonal antibodies

    Accurate prediction of the clinical pharmacokinetics of new therapeutic entities facilitates decision making during drug discovery, and increases the probability of success for early clinical trials. Standard ...

    Patrick M. Glassman… in Journal of Pharmacokinetics and Pharmacodynamics (2016)

  3. No Access

    Article

    Scale-up of a physiologically-based pharmacokinetic model to predict the disposition of monoclonal antibodies in monkeys

    Preclinical assessment of monoclonal antibody (mAb) disposition during drug development often includes investigations in non-human primate models. In many cases, mAb exhibit non-linear disposition that relates...

    Patrick M. Glassman, Yang Chen… in Journal of Pharmacokinetics and Pharmacody… (2015)