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Article
Oral urea in the treatment of secondary tumours in the liver
Twenty patients with secondary liver tumours, predominantly from colorectal carcinoma, were treated with oral urea at a daily dose of 8 gm-2. Treatment was well tolerated without side-effects. No objective res...
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Article
Low field strength magnetic resonance imaging of bone marrow in patients with malignant lymphoma
Detection of bone marrow infiltration by lymphoma with low field strength magnetic resonance imaging (MRI) has been assessed. Measurements of spin lattice relaxation time (T1) were made in 31 patients with lym...
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Article
Low field strength magnetic resonance imaging of the spleen: results from volunteers and patients with lymphoma
Low field strength (0.08 Tesla) magnetic resonance imaging (MRI) of the spleen with spin lattice relaxation time (T1) measurement was performed on a total of 79 healthy volunteers and 62 patients with lymphoma...
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Article
Radiotherapy for stage I Hodgkin's disease: 20 years experience at St Bartholomew's Hospital
One hundred and one consecutive patients with newly diagnosed stage I Hodgkin's disease (HD) received treatment at St Bartholomew's Hospital, between 1968 and 1987, with a median follow-up of 12 years. Eleven ...
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Article
Phase II trial of UFT in advanced colorectal and gastric cancer
A phase II trial of continuous oral therapy with UFT, a combination of uracil and the 5-fluorouracil analogue 1-(2-tetrahydrofuryl)-5-fluorouracil (Futraful, Ftorafur), was conducted in 40 patients with advanc...
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Article
A less toxic regimen of 5-fluorouracil and high-dose folinic acid for advanced gastrointestinal adenocarcinomas
The combination of high-dose folinic acid with 5-fluorouracil has shown improved response rates in several trials in advanced colorectal carcinoma. This however is at the expense of increased toxicity: regimen...
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Article
Patterns of survival in patients with advanced Hodgkin's disease (HD) treated in a single centre over 20 years
A total of 164 consecutive adults with newly confirmed stage IIIB, IVA or IVB Hodgkin's disease (HD) commenced cyclical combination chemotherapy comprising mustine, vinblastine, prednisolone and procarbazine (...
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Article
Tumour markers for prediction of survival and monitoring of remission in small cell lung cancer
Levels of the tumour markers neurone specific enolase (NSE), lactate dehydrogenase (LDH), chromogranin A (ChrA) and carcinoembryonic antigen (CEA) were measured in serum taken at presentation and during treatm...
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Article
Combination chemotherapy for intermediate and high grade non-Hodgkin's lymphoma
One hundred and eighteen consecutive adults with newly diagnosed intermediate and high-grade non-Hodgkin's lymphoma were treated with chemotherapy comprising Doxorubicin, Cyclophosphamide, Vincristine and Pred...
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Article
Double modulation of 5-fluorouracil with interferon α2a and high-dose leucovorin: a phase I and II study
Twenty-nine patients with adenocarcinomas of gastrointestinal or unknown primary, and three with advanced neuroendocrine tumours, were entered into a study of bolus plus infusional 5-fluorouracil (FUra) modula...
