20 Result(s)
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Open AccessBlood Biomarkers from Research Use to Clinical Practice: What Must Be Done? A Report from the EU/US CTAD Task Force
Timely and accurate diagnosis of Alzheimer’s disease (AD) in clinical practice remains challenging. PET and CSF biomarkers are the most widely used biomarkers to aid diagnosis in clinical research but present ...
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Open AccessFramework Implementation of the INSPIRE ICOPE-CARE Program in Collaboration with the World Health Organization (WHO) in the Occitania Region
Limiting the number of dependent older people in coming years will be a major economic and human challenge. In response, the World Health Organization (WHO) has developed the «Integrated Care for Older People ...
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Open AccessCognitive Function and Amyloid Marker in Frail Older Adults: The Cogfrail Cohort Study
Frailty and cognitive impairment are common manifestations of the ageing process and are closely related. But the mechanisms linking aging, physical frailty, and cognitive disorders, are complex and remain unc...
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Open AccessThe INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort)
The Geroscience field focuses on the core biological mechanisms of aging, which are involved in the onset of age-related diseases, as well as declines in intrinsic capacity (IC) (body functions) leading to dep...
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A Web-Based Multidomain Lifestyle Intervention for Older Adults: The eMIND Randomized Controlled Trial
To describe the feasibility and acceptability of a 6-month web-based multidomain lifestyle training intervention for community-dwelling older people and to test the effects of the intervention on both function...
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Toulouse Alzheimer’s Clinical Research Center Recovery after the COVID-19 Crisis: Telemedicine an Innovative Solution for Clinical Research during the Coronavirus Pandemic
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A web-based multidomain lifestyle intervention with connected devices for older adults: research protocol of the eMIND pilot randomized controlled trial
Multidomain interventions composed of nutritional counseling, exercise and cognitive trainings have shown encouraging results as effective preventive strategies delaying age-related declines. However, these in...
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Analysing time to event data in dementia prevention trials: The example of the guidage study of EGB761®
Time-to-event analysis is frequently used in medical research to investigate potential diseasemodifying treatments in neurodegenerative diseases. Potential treatment effects are generally evaluated using the l...
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Cognitive frailty: Rational and definition from an (I.A.N.A./I.A.G.G.) International Consensus Group
The frailty syndrome has recently attracted attention of the scientific community and public health organizations as precursor and contributor of age-related conditions (particularly disability) in older perso...
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Multidisciplinary team meetings (MDTM) in detection of Alzheimer’s disease: Data from the idem study
The National Institute for Health and Clinical Excellence (NICE) in the United Kingdom, the Institut fur Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWIG) in Germany and the Haute Autorité de Santé (...
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Essais thérapeutiques de phase I dans la maladie d’Alzheimer
Les traitements de la maladie d’Alzheimer (MA) actuellement disponibles ont des effets cliniques modestes et n’interfèrent pas dans la cascade physiopathologique présumée de cette pathologie. La recherche de n...
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Differences in resource use and costs of dementia care between European countries: Baseline data from the ictus study
This study aimed to estimate the costs of formal and informal care of patients with Alzheimer's disease, to compare care costs across European countries and identify potential differences in cost patterns betw...
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Clinical trials in Alzheimer’s disease: un congrès à l’heure de la prévention
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Mild Alzheimer’s disease: A «Position Paper»
Under the auspices of the Société Française de Gériatrie et Gérontologie, a multi-disciplinary group of specialists in geriatrics, neurology, epidemiology, psychiatry, neuroradiology and nuclear medicine met w...
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Rapid cognitive decline in Alzheimer’s disease. Consensus paper
The rate of cognitive decline in Alzheimer’s disease (AD) varies considerably between individuals, with some subjects showing substantial deterioration and others showing little or no change over the course of...
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1st Conference Clinical Trials on Alzheimer’s Disease September 17-18-19, 2008 School of Medecine Montpellier, France
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Prevention of progression to dementia in the elderly: Rationale and proposal for a health-promoting memory consultation (an IANA task force)
Alzheimer’s disease (AD) is the most frequent form of dementia and according to the most recent estimation it affects nearly 27 million people in the world. The onset of the disease is generally insidious. It ...
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A randomized trial of the impact of a specific care plan in 1120 Alzheimer’s patients (PLASA study) over a two-year period: Design and baseline data
Objectives: To describe the design and baseline patient characteristics of a multicomponent specific care and assistance plan (PLASA) study in Alzheimer’s Disease (AD). The study is designed to evaluate the effec...
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Memory complaints to the general practitioner: Data from the GuidAge study
Memory complaints are relatively common in elderly people, although they are not always reported to the general practitioner (GP). These subjective complaints do not necessarily correlate with objective measur...
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One-leg standing balance and functional status in a population of 512 community-living elderly persons
The objective of this cross-sectional study (whose baseline data were drawn from a longitudinal population study) was to determine if oneleg standing balance might be a useful marker of functional status in el...
