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Article
THERAPEUTIC RESPONSE TO RECOMBINANT IGF-1 IN THIRTY TWO PATIENTS WITH GROWTH HORMONE INSENSITIVITY
30 patients with GH insensitivity syndrome (GHIS) (Laron syndrome) and 2 patients with GH gene deletion were included in a multicentre trial of recombinant human IGF-1 (rhIGF-1). The GHIS patients, from 9 Euro...
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Article
EFFECT ON GROWTH VELOCITY OF DOSE-FREQUENCY OF GROWTH HORMONE (GH) TREATMENT (Rx) IN IDIOPATHIC GH INSUFFICIENCY (IGHD) PREPUBERTAL CHILDREN: THE KABI PHARMACIA INTERNATIONAL GROWTH STUDY (KIGS) EXPERIENCE
Growth Velocity (GV) In response to recombinant GH Rx was analyzed using KIGS data base. IGHD was based on classical criteria : short stature, slow growth velocity; GH peak response at 2 provocative tests belo...
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Article
DEMOGRAPHY OF CHILDREN ON GROWTH HORMONE (GH) TREATMENT ENROLLED 1987–1992 IN KIGS Kabi Pharmacia International Growth Study
In 1987, collection of efficacy and safety information of children on Growth Hormone (GH) treatment started within KIGS. Today, 8887 patients are enrolled from 28 countries. Parental, perinatal and pretreatmen...
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Article
PHARMACOKINETIC PEOFILE OF AN I.V. AND S.C. DOSE OF RECOMBINANT HUMAN GROWTH HORMONE
8 healthy male volunteers aged 21-35 years were given an i.v. dose of recombinant somatropin 0.1 IU/kg BW at 8 a.m. after 12 hours' fasting. Blood was sampled every 5th minute during 2 hours for GH measurement...
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Article
HETEROGENEITY IN JUVENILE THYROTOXICOSIS
In this study we have examined factors, present at diagnosis of juvenile thyrotoxicosis, for their possible prognostic significance with respect to outcome of antithyroid drug therapy. Thirty-six children (<17...
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Article
CONGENITAL ADRENAL HYPERPLASIA DUE TO 3 beta-HYDROXYSTEROID DEHYDROGENASE (3bHSD) DEFICIENCY
An eight weeks old boy, first child to nonconsanguineous parents of Swedish extraction, presented with severe dehydration and salt loss. Plasma Na 109 and plasma K 8.7mval/l. He had a phallus 1,5 cm in length,...
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Article
THE EFFECT OF NORMAL DEVELOPMENT ON COMPENSATORY RENAL GROWTH
Rats were nephrectomized (Nx) or sham-operated (S) at the age of 5, 12 and 40 days. One group of rats was Nx in utero 3-4 days before delivery. Light microscopy studies of renal structural development were car...