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  1. Article

    THERAPEUTIC RESPONSE TO RECOMBINANT IGF-1 IN THIRTY TWO PATIENTS WITH GROWTH HORMONE INSENSITIVITY

    30 patients with GH insensitivity syndrome (GHIS) (Laron syndrome) and 2 patients with GH gene deletion were included in a multicentre trial of recombinant human IGF-1 (rhIGF-1). The GHIS patients, from 9 Euro...

    M O Savage, P Wilton, M B Ranke, P G Chatelain, W F Blum… in Pediatric Research (1993)

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  2. Article

    EFFECT ON GROWTH VELOCITY OF DOSE-FREQUENCY OF GROWTH HORMONE (GH) TREATMENT (Rx) IN IDIOPATHIC GH INSUFFICIENCY (IGHD) PREPUBERTAL CHILDREN: THE KABI PHARMACIA INTERNATIONAL GROWTH STUDY (KIGS) EXPERIENCE

    Growth Velocity (GV) In response to recombinant GH Rx was analyzed using KIGS data base. IGHD was based on classical criteria : short stature, slow growth velocity; GH peak response at 2 provocative tests belo...

    P Chatelain, O Guilbaud, P Wilton, R Gunnarsson in Pediatric Research (1993)

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  3. Article

    DEMOGRAPHY OF CHILDREN ON GROWTH HORMONE (GH) TREATMENT ENROLLED 1987–1992 IN KIGS Kabi Pharmacia International Growth Study

    In 1987, collection of efficacy and safety information of children on Growth Hormone (GH) treatment started within KIGS. Today, 8887 patients are enrolled from 28 countries. Parental, perinatal and pretreatmen...

    K Albensson-Wikland, P Wilton, A Wallström, L Karlsson in Pediatric Research (1993)

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  4. Article

    PHARMACOKINETIC PEOFILE OF AN I.V. AND S.C. DOSE OF RECOMBINANT HUMAN GROWTH HORMONE

    8 healthy male volunteers aged 21-35 years were given an i.v. dose of recombinant somatropin 0.1 IU/kg BW at 8 a.m. after 12 hours' fasting. Blood was sampled every 5th minute during 2 hours for GH measurement...

    P Wilton, L Widlund, O Guilbaud, M Ritzén in Pediatric Research (1988)

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  5. Article

    HETEROGENEITY IN JUVENILE THYROTOXICOSIS

    In this study we have examined factors, present at diagnosis of juvenile thyrotoxicosis, for their possible prognostic significance with respect to outcome of antithyroid drug therapy. Thirty-six children (<17...

    P Wilton, P A Dahlberg, F A Karisson in Pediatric Research (1986)

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  6. Article

    CONGENITAL ADRENAL HYPERPLASIA DUE TO 3 beta-HYDROXYSTEROID DEHYDROGENASE (3bHSD) DEFICIENCY

    An eight weeks old boy, first child to nonconsanguineous parents of Swedish extraction, presented with severe dehydration and salt loss. Plasma Na 109 and plasma K 8.7mval/l. He had a phallus 1,5 cm in length,...

    P Wilton, T Curstedt in Pediatric Research (1984)

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  7. Article

    THE EFFECT OF NORMAL DEVELOPMENT ON COMPENSATORY RENAL GROWTH

    Rats were nephrectomized (Nx) or sham-operated (S) at the age of 5, 12 and 40 days. One group of rats was Nx in utero 3-4 days before delivery. Light microscopy studies of renal structural development were car...

    P Wilton, L Larsson in Pediatric Research (1980)

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