6 Result(s)
within
Oscar Krijgsman
Cancer Research
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Article
Map** phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities
Phosphorylation networks intimately regulate mechanisms of response to therapies. Map** the phospho-catalytic profile of kinases in cells or tissues remains a challenge. Here, we introduce a practical high-t...
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Article
Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma
Adjuvant ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) both improve relapse-free survival of stage III melanoma patients1,2. In stage IV disease, the combination of ipilimumab + nivolumab is superior to ipil...
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Article
Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors
Expression of AXL earmarks melanoma cells resistant to BRAF and MEK inhibitors that either pre-exist in treatment-naive tumors or emerge in response to therapy. The combination of an AXL-MMAE antibody-drug con...
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Article
Detection limits of DNA copy number alterations in heterogeneous cell populations
Array Comparative Genomic Hybridization (aCGH) is a widely used technique to assess chromosomal copy number alterations. Chromosomal content, however, is often not uniform throughout cell populations. Here we ...
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Article
Open AccessGenomic aberrations relate early and advanced stage ovarian cancer
Because of the distinct clinical presentation of early and advanced stage ovarian cancer, we aim to clarify whether these disease entities are solely separated by time of diagnosis or whether they arise from d...
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Article
TSPYL5 suppresses p53 levels and function by physical interaction with USP7
The genetic locus encompassing TSPYL5 is frequently amplified in breast cancer. TSPYL5 is now shown to repress p53 accumulation by interacting with and inhibiting the p53 de-ubiquitylating enzyme USP7.
