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Article
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of pre-metastatic liver biopsies would classify patients according to thei...
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Article
Open AccessLymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial
Pancreatic and colorectal cancers are often KRAS mutated and are incurable when tumor DNA or protein persists or recurs after curative intent therapy. Cancer vaccine ELI-002 2P enhances lymph node delivery and...
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Article
Open AccessPancreatic cancer stem cells may define tumor stroma characteristics and recurrence patterns in pancreatic ductal adenocarcinoma
Herein, we investigate the relationship between pancreatic stem cell markers (PCSC markers), CD44, and epithelial-specific antigen (ESA), tumor stroma, and the impact on recurrence outcomes in pancreatic ducta...
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Article
Immunohistochemical null-phenotype for mismatch repair proteins in colonic carcinoma associated with concurrent MLH1 hypermethylation and MSH2 somatic mutations
Microsatellite instability, a well-established driver pathway in colorectal carcinogenesis, can develop in both sporadic and hereditary conditions via different molecular alterations in the DNA mismatch repair...
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Reference Work Entry In depth
Pathologic Classification and Biological Behavior of Pancreatic Neoplasia
Pancreatic neoplasms are classified according to the normal cells they recapitulate. These neoplasms’ clinicopathologic and biologic characteristics are determined mostly by their cellular lineage. Most are of...
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Living Reference Work Entry In depth
Pathologic Classification and Biological Behavior of Pancreatic Neoplasia
Pancreatic neoplasms are classified according to the normal cells they recapitulate. These neoplasms’ clinicopathologic and biologic characteristics are determined mostly by their cellular lineage. Most are of...
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Reference Work Entry In depth
Pathologic Classification and Biological Behavior of Pancreatic Neoplasia
Pancreatic neoplasms are classified according to which normal cell type of this organ they recapitulate, because the clinicopathologic and biologic characteristics of tumors are determined or manifested mostly...